Research progress of stem cells in corneal wound healing

Authors: Chen Hongli,  Yan Chenxi,  Fu Yao

DOI: 10.3760/cma.j.issn.2095-0160.2018.11.014
Published 2018-11-10
Cite as Chin J Exp Ophthalmol, 2018,36(11): 883-886.

Abstract

As the outermost part, cornea plays a critical role in protecting the eyeball and functions as main component of the dioptric media.Trauma, inflammation, malnutrition, inherited diseases, tumors, contact lens problems and complications of refractive surgeries may cause corneal injury.However, there are still no perfect treatments for severe corneal damage.Progresses have been made in the research field of corneal stem cells in recent years.Epithelial stem cells play an important role in corneal wound healing, whereas the contribution of stromal and endothelial stem cells is less studied.Moreover, corneal cells differentiated from alternative cell sources have a brilliant prospect in transplantation.This article reviewed the recent research progress of stem cells in the corneal epithelial, stromal and endothelial wound healing.

Key words:

Cornea; Stem cell; Corneal epithelium; Keratocyte; Corneal endothelium; Wound healing

Contributor Information

Chen Hongli
Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China
Yan Chenxi
Fu Yao
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Updated: September 4, 2019 — 10:51 am