Category: 2018, No. 11

Applications of CRISPR/Cas9 genome editing technology in gene therapy for hereditary eye diseases

Authors:  Wu Shijing,  Sui Ruifang DOI: 10.3760/cma.j.issn.2095-0160.2018.11.016 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 892-896. Abstract Clustered regulatory interspaced short palindromic repeat (CRISPR)/CRISPR associated nuclease (Cas) system is an adaptive immune system that confers resistance to exogenous virus or plasmid in bacteria and archaea, over the 30 years since its discovery, researchers have a better […]

Research progress of ocular surface reconstruction with ex vivo cultured tissue engineered cell sheet

Authors:  Wang Fuyan,  Zhou Qingjun,  Xie Lixin DOI: 10.3760/cma.j.issn.2095-0160.2018.11.015 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 887-891. Abstract Limbal stem cells (LSCs), the source of corneal epithelial cells, play an important role in the ocular surface.In recent years, with the development of somatic stem cell application and tissue engineering, biomaterials and cell culture technology, progress has […]

Research progress of stem cells in corneal wound healing

Authors: Chen Hongli,  Yan Chenxi,  Fu Yao DOI: 10.3760/cma.j.issn.2095-0160.2018.11.014 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 883-886. Abstract As the outermost part, cornea plays a critical role in protecting the eyeball and functions as main component of the dioptric media.Trauma, inflammation, malnutrition, inherited diseases, tumors, contact lens problems and complications of refractive surgeries may cause corneal […]

The visual basis of the biological clock “sees” the light: intrinsically photosensitive retinal ganglion cells

Authors: Zhang Jingxue,  Wang Ningli DOI: 10.3760/cma.j.issn.2095-0160.2018.11.013 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 879-882. Abstract Mammalian eyes mediate both image-forming and non-image-forming visual functions.Non-image-forming vision provides a measure of the ambient light for the purposes of synchronization of circadian clocks to light/dark cycles and regulation of pupil size, pineal melatonin production and other functions.Traditionally, […]

Research progress of stem cells in the treatment of retinal degenerative diseases

Authors: Zhang Kefan,  Qu Xiuxia,  Fan Guoping DOI: 10.3760/cma.j.issn.2095-0160.2018.11.011 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 871-877. Abstract Eyes are important human organs, and retinal degenerative diseases can cause irreversible blindness.Up to date, cell transplantation is an important method for the treatment of degenerative eye diseases.Because the number of adult eye stem cells is rather limited, […]

Research progress cellular reprogramming technology and induced pluripotent stem cells for retinal diseases treatment

Authors: Fang Lyujie,  Ding Yong,  Liang Helena,  Wong Raymond Ching-Bong DOI: 10.3760/cma.j.issn.2095-0160.2018.11.009 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 864-869. Abstract Current advances in cellular reprogramming technology has demonstrated that the identity of a cell can be converted by the use of master transcription factors to reprogram the transcriptome.Notably, this allows us to convert somatic cells into […]

The efficiency of micropulse laser trabeculoplasty for open angle glaucoma and ocular hypertension patients

Authors: Hong Ying,  Song Sijia,  Li Shushan,  Liu Bo,  Zhang Chun DOI: 10.3760/cma.j.issn.2095-0160.2018.11.008 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 859-863. Abstract Objective To evaluate the efficiency and safety of micropulse laser trabeculoplasty (MLT) for open angle glaucoma (OAG) patients and ocular hypertension (OHT) patients. Methods A prospective self-controlled study was designed.Fifty-six eyes of 56 OAG and OHT […]

Safety of autologous bone marrow mesenchymal stem cells transplantation in proliferative diabetic retinopathy patients

Authors: Liang Qingling,  Li Shiying,  Duan Ping,  Liu Yong,  Yin Zhengqin DOI: 10.3760/cma.j.issn.2095-0160.2018.11.007 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 852-858. Abstract Objective To investigate the safety of autologous bone marrow mesenchymal stem cells (ABMSCs) transplantation into the subretinal space for the treatment of proliferative diabetic retinopathy (PDR). Methods The clinical data of four PDR patients (four eyes) […]

c-Fos expression in visual cortex of infant rhesus monkeys with myopia induced by hyperopic defocus

Authors: Wu Junshu,  Sha Xiangyin,  Zheng Hua,  Liu Yinghui,  Ge Jian DOI: 10.3760/cma.j.issn.2095-0160.2018.11.006 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 847-851. Abstract Objective To observe c-Fos expression in visual cortex of infant rhesus monkeys with myopia induced by hyperopic defocus and preliminarily investigate the possibility of visual cortex participating in myopia. Methods Eight SPF grade healthy infant rhesus […]

Changes of the immune-microenvironment in retinal degeneration process of RCS rat

Authors:  Tang Huanyu,  Lu Ziyang,  He Juncai,  Gao Yuan,  Yin Zhengqin DOI: 10.3760/cma.j.issn.2095-0160.2018.11.005 Published 2018-11-10 Cite as Chin J Exp Ophthalmol, 2018,36(11): 839-846. Abstract Objective To explore the immune-microenvironment of the retinas at different stages of retinal degeneration in Royal College of Surgeon (RCS) rats. Methods RCS-rdy–-P+ (RCS) rats at early stage (P20), middle stage (P40) and late stage (P60) […]