Role of microRNA-21 in the occurrence and development of ophthalmic diseases

Authors: Sun Jijun,  Ruan Qingguo,  Shi Weiyun
DOI: 10.3760/cma.j.cn115989-20191007-00428
Published 2022-10-10
Cite asChin J Exp Ophthalmol, 2022, 40(10): 986-991.

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MicroRNA (miRNA) is a short noncoding RNA, which can regulate gene expression.miR-21 is one of the human miRNAs identified earlier.As an oncovirus, it is involved in the post-transcriptional regulation of gene and plays important roles in cell proliferation, apoptosis and differentiation.In addition, miR-21 promotes inflammatory responses and also plays a key role in regulating the function of immune system.Recent studies have shown that miR-21 could be detected in corneal fibroblasts cells, retinal pigment epithelial cells, retinal microvascular endothelial cells, retinal microglia and other eye-derived cells.Furthermore, miR-21 plays an important part in the development of various eye diseases including retinoblastoma, uveal melanoma, corneal alkali burn, proliferative vitreoretinopathy, diabetic retinopathy and uveitis.Further studies have shown that inhibited expression of miR-21 can treat retinoblastoma and rescue vision loss caused by corneal neovascularization and diabetic retinopathy, while overexpression of miR-21 can promote corneal epithelial healing and treat primary open-angle glaucoma and retinal degeneration.This review summarized the recent research progress of the role of miR-21 in eye diseases.

Key words:

MicroRNA; Eye diseases; MicroRNA-21; Regulation of gene

Contributor Information

Sun Jijun

Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, China

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China

School of Ophthalmology, Shandong First Medical University, Jinan 250000, China

Ruan Qingguo

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China

Shi Weiyun

Eye Institute of Shandong First Medical University, Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, China

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Qingdao 266071, China

School of Ophthalmology, Shandong First Medical University, Jinan 250000, China

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