Epigenetic regulation and retinal degenerative diseases

Authors: Zhang Hua,  Pang Jijing
DOI: 10.3760/cma.j.cn115989-20191015-00442
Published 2022-10-10
Cite asChin J Exp Ophthalmol, 2022, 40(10): 981-985.

Abstract                                     [View PDF] [Read Full Text

Epigenetics pertains to heritable alterations in gene expression when the nucleotide sequence remains unchanged.Epigenetic regulation mechanisms are diverse, among which DNA methylation, histone modification and non-coding RNA (ncRNA) regulation have been studied in depth.Epigenetic regulation is associated with a variety of human diseases.In the occurrence and development of retinal degenerative diseases, many epigenetic regulation processes such as DNA methylation, histone acetylation and ncRNA regulation have changed.DNA methylation is one of the important regulation processes in retinal degeneration.Aberrant DNA methylation patterns are associated with retinitis pigmentosa (RP), age-related macular degeneration (AMD), inflammation and oxidative stress.Histone acetylation is associated with RP, diabetic retinopathy (DR), glaucoma and retinal nerve ischemic injury.NcRNA is associated with RP, AMD, pathological angiogenesis, and DR.In this article, the application of epigenetic regulation in retinal degeneration was reviewed.

Key words:

Epigenetic regulation; DNA methylation; Histone acetylation; Non-coding RNA; Retinal degeneration

Contributor Information

Zhang Hua

The West China Institutes for Women and Children’s Health, West China Second University Hospital, Sichuan University, Chengdu 610041, China

Pang Jijing

Department of Genetic Diseases, He Eye Specialist Hospital, Shenyang 110000, China

(Read 13 times, 1 visits today)