Role of proteins containing leucine rich repeat motif in ophthalmic diseases

Leucine rich repeat (LRR) is a common protein structure that exists in many kinds of proteins and plays a crucial role in maintaining the biological function of these proteins.Eye tissue is an important sensory system and connects with nervous system through the optic nerve.There are relevant studies to confirm that a variety of LRR proteins in eye tissue, such as small leucine-rich proteoglycans, keratocan, leucines-rich repeat-containing 8, NOD-like receptor thermal protein domain associated protein 3 and NYX, which take part in multiple ocular diseases including myopia, retinal diseases, glaucoma, uveitis, night blindness, corneal diseases and eye fibropathy.This article focuses on the functional research of LRR-related proteins in ophthalmic diseases.The hope is that focusing on LRR-related proteins crucial to ocular development will provide new ideas for the diagnosis and treatment of various ophthalmic diseases.

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