Role of retinal microglia-mediated parainflammation in age-related macular degeneration

Authors: Wang Yuwei,  Li Jing
DOI: 10.3760/cma.j.cn115989-20210922-00526
Published 2021-11-10
Cite asChin J Exp Ophthalmol, 2021, 39(11): 1021-1024.

Abstract

Age-related macular degeneration (AMD) is a disease caused by multiple factors such as age, genetics and environmental risks.Inflammation plays an important role in the pathogenesis of AMD.Between the basal level and the classic inflammatory response, the parainflammation plays an important role in maintaining tissue homeostasis.The dysregulated parainflammation is manifested as uncontrollable chronic inflammation.In recent years, a large number of studies have focused on the contribution of chronic non-resolving inflammation to the development of AMD, in which microglial dysfunction plays a significant part.The abnormal activation of microglia caused by various factors can lead to the disorder of the parainflammation.The causes and results of retinal microglial dysfunction were reviewed in this article, so as to focus on dysregulated parainflammation in AMD.

Key words:

Macular degeneration; Parainflammation; Retina; Microglia

Contributor Information

Wang Yuwei

Department of Ophthalmology, Affiliated Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Wang Yuwei is now working in Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China

Li Jing

Department of Ophthalmology, Affiliated Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

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Updated: November 25, 2021 — 8:21 am