Specialized proresolving lipid mediators and eye diseases

Authors: Zhu Yingting,  Li Yiqing,  Zhuo Yehong
DOI: 10.3760/cma.j.cn115989-20200607-00402
Published 2021-07-10
Cite asChin J Exp Ophthalmol, 2021, 39(7): 649-654.

Abstract

Novel endogenous lipid-mediated molecules including lipoxins, resolvins, protectins, and maresin families are discovered recently and are collectively called specialized proresolving lipid mediators (SPMs). SPMs have the potential to promote the resolution of inflammation, the elimination of pathogen, and the restoration of homeostasis.Meanwhile, SPMs also have the function of apoptosis inhibition, wound healing, and neuroprotection.SPMs play an important role in the treatment of many eye diseases, such as corneal inflammatory diseases, dry eye, uveitis, retinal and choroidal neovascularization diseases, etc.In this article, the mechanisms involving the role of SPMs in the occurrence and progress of eye diseases were reviewed to provide a general new basis for the future development of new ophthalmic drugs.

Key words:

Specialized proresolving lipid mediators; Cornea; Dry eye; Uveitis; Retina; Glaucoma

Contributor Information

Zhu Yingting

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China

Li Yiqing

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China

Zhuo Yehong

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China

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Updated: July 27, 2021 — 1:06 am