Category: 2021, No. 07

Chinese experts consensus of treat-and-extend regimen for management of neovascular age-related macular degeneration by intravitreal injection of aflibercept (2021)

Author: Treat-and-Extend Regimen for Management of Neovascular Age-related Macular Degeneration Chinese Experts Consensus Group DOI: 10.3760/cma.j.cn115989-20210311-00162 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 577-584. Abstract Neovascular age-related macular degeneration (nAMD) is one of the leading causes of visual impairment and blindness.Using treat-and-extend (T&E) regimen, aflibercept has been proven effective in nAMD treatment.Decreased intravenous […]

Protective effect and mechanism of cx3cr1 antibody intravitreal injection in microcirculation of retinal ischemia-reperfusion injury in mice

Authors: Li Juanjuan,  Chen Chen,  Li Yan,  Zhang Liwei DOI: 10.3760/cma.j.cn115989-20200104-00004 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 585-592. Abstract Objective To investigate the protective effect of C-X3-C motif chemokine receptor 1 (cx3cr1) antibody, a microglia activation inhibitor, on microcirculation during retinal ischemia reperfusion (RIR) and its possible mechanism. Methods One hundred and […]

Protective effect of asiatic acid on blood-retinal barrier in diabetic rats

Authors: Fang Mengyuan,  Li Qiuming,  Yang Xin,  Wan Weiwei,  Long Yang,  Liu Hongzhuo,  Wan Wencui DOI: 10.3760/cma.j.cn115989-20201024-00713 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 593-601. Abstract Objective To investigate the protective effect of asiatic acid (AA) on blood-retinal barrier (BRB) in diabetic rats and its possible mechanism. Methods Ninety-six healthy 8-week-old male SD […]

Research on screening system of myopic maculopathy based on deep convolution neural network

Authors: Shi Chunsheng,  Liu Lei,  Wang Yaru,  Wang Zefei DOI: 10.3760/cma.j.cn115989-20191115-00495 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 602-608. Abstract Objective To develop a fully automatic detection system based on the deep convolution neural network (DCNN) for screening myopic maculopathy (MMD) and identifying its severity. Methods Six thousand and sixty-eight fundus images were […]

Peripheral retinal fluorescence features of ultra-wide fundus fluorescein angiography in normal fundus eyes

Authors: Wang Xiaoling,  Chen Changzheng,  Xu Amin,  Yi Zuohuizi,  He Lu,  Liu Juejun,  Zheng Hongmei DOI: 10.3760/cma.j.cn115989-20190426-00201 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 609-613. Abstract Objective To analyze the peripheral retinal fluorescence characteristics of normal fundus on ultra-wide field fluorescein angiography (UWFA) images. Methods A cross-sectional study was conducted.Ninety-five patients (190 eyes) […]

Optical coherence tomography angiography of macula in retinopathy of prematurity children with single treatment history

Authors: Zhao Xinyu,  Wu Zhenquan,  Zhang Guoming DOI: 10.3760/cma.j.cn115989-20201104-00740 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 614-618. Abstract Objective To observe the changes of macular morphology and best corrected visual acuity (BCVA) in children with retinopathy of prematurity (ROP) after single treatment of laser photocoagulation or intravitreal injection of ranibizumab (IVR) by optical […]

Risk factors and treatment outcome of recurrent acanthamoeba keratitis after corneal transplantation

Authors: Feng Lijuan,  Jia Yanni,  Li Fengjie,  Dong Chunxiao,  Shi Weiyun,  Wang Ting DOI: 10.3760/cma.j.cn115989-20200930-00673 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 619-625. Abstract Objective To investigate the risk factors and treatment outcome of recurrent Acanthamoeba keratitis (AK) after corneal transplantation. Methods A serial case-observational study was carried out.Twenty-eight eyes of 28 patients […]

Clinical manifestation and treatment of ocular immune reconstitution inflammatory response syndrome in acquired immunodeficiency syndrome patients with cytomegalovirus retinitis

Authors: Kong Wenjun,  Wei Wenbin,  Xie Lianyong,  Chen Chao,  Du Kuifang DOI: 10.3760/cma.j.cn115989-20200317-00179 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 626-631. Abstract Objective To investigate the ocular characteristics and treatment prognosis of ocular immune reconstruction inflammatory syndrome (IRIS) in patients with cytomegalovirus retinitis (CMVR) complicated with acquired immunodeficiency syndrome (AIDS). Methods A serial […]

Analysis of target cytokines affecting OCTA changes following anti-VEGF treatment in PCV eyes

Authors: Xu Qing,  Qiao Lei,  Gong Chaoju,  Feng Ruifang,  Liu Yalu,  Sun Yongcheng,  Zhang Yipeng,  Li Suyan DOI: 10.3760/cma.j.cn115989-20210319-00187 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 632-639. Abstract Objective To explore the predictability cytokines in aqueous humor affecting optical coherence tomography angiography (OCTA) parameters after anti-vascular endothelial growth factor (VEGF) treatment in patients […]

Research progress of intravitreal injections for nonarteritic anterior ischemic optic neuropathy

Authors: He Lu,  Chen Changzheng DOI: 10.3760/cma.j.cn115989-20201104-00739 Published 2021-07-10 Cite asChin J Exp Ophthalmol, 2021, 39(7): 641-644. Abstract Nonarteritic anterior ischemic optic neuropathy (NAION) is a common type of acute optic neuropathy in elderly, characterized by optic disc edema and visual field defect.At present, there is no generally accepted treatment, and the treatment of NAION […]