Advances in rodent models of retinal neovascularization

Authors: Xu Qianhui,  Chen Jun,  Shao Yi
DOI: 10.3760/cma.j.cn115989-20200211-00064
Published 2022-10-10
Cite asChin J Exp Ophthalmol, 2022, 40(10): 996-998.

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Retinal neovascularization (RNV) originating from retinal blood vessels is one of the main pathological features of many ocular diseases that affect vision.It is inseparably linked to choroidal neovascularization and can cause a series of complications, for instance, visual impairment as diseases progress.Pathological manifestations such as RNV and ischemic retinopathy can be constructed in mouse models by laser induction and surgery.With the continuous development of genetic engineering technology, genetic engineering has been applied in the establishment of a variety of RNV mouse models.This article introduced the RNV mouse models of laser-induced venous occlusion, oxygen-induced retinopathy, vascular endothelial growth factor high expression, and double gene knockout.These genetically engineered mouse models can have many clinical manifestations of RNV in humans.Mechanisms of inducing RNV in various types of mouse models are different, thus types and the course of RNV symptoms induced can be different.RNV mouse models induced by various mechanisms have played a role in the pathological study of RNV.This reviewed aimed to sort RNV mouse models for medical staff and researchers to evaluate new treatments for the disease, provide experimental objects for new drugs and lay a basis for clinical diagnosis and treatment.

Key words:

Retinal neovascularization; Genetic engineering; Disease models, animal; Mice

Contributor Information

Xu Qianhui

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Chen Jun

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Shao Yi

Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China

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