Authors: Gong Wei, Liu Kun, He Xiangui DOI: 10.3760/cma.j.cn115989-20210330-00221 Published 2023-09-10 Cite as Chin J Exp Ophthalmol, 2023, 41(9): 939-943. Abstract 【Download PDF】 【Read Full Text】 Myopia has become a serious public health problem, but its pathogenesis is still unclear, and effective interventions […]
Tag: DNA methylation
Regulatory effect of CCCTC binding factor on Bcl-2 gene in pterygium and its mechanism
Authors: Yin Xiuqin, Yu Li, Yi Lu, Fang Jiahua DOI: 10.3760/cma.j.cn115989-20211108-00611 Published 2023-05-10 Cite as Chin J Exp Ophthalmol, 2023, 41(5): 421-427. Abstract [Download PDF] [Read Full Text] Objective To investigate the regulation of transcription factor CCCTC binding factor (CTCF) on the […]
Epigenetics, diseases and therapy in ophthalmology
Authors: Zhe Jing, Xiaomeng Wu DOI: 10.3760/cma.j.issn.2095-0160.2015.08.001 Published 2015-08-10 Cite as Chin J Exp Ophthalmol, 2015,33(8): 673-677. Abstract [Download PDF] [Read Full Text] Heritable changes in gene expression are regarded as epigenetics, which do not involve coding sequence modifications. The study of […]
Epigenetic regulation and retinal degenerative diseases
Authors: Zhang Hua, Pang Jijing DOI: 10.3760/cma.j.cn115989-20191015-00442 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 981-985. Abstract [View PDF] [Read Full Text] Epigenetics pertains to heritable alterations in gene expression when the nucleotide sequence remains unchanged.Epigenetic regulation […]
Association between MeCP2 and proliferative vitreoretinopathy under the regulation of tumor necrosis factor
Authors: Xu Yuejuan, Li Xiaohua DOI: 10.3760/cma.j.cn115989-20191111-00491 Published 2020-06-10 Cite as Chin J Exp Ophthalmol, 2020,38(06): 548-552. Abstract [View PDF] [Read Full Text] Proliferative vitreoretinopathy (PVR) is an ocular fundus disease involving multiple cytokines.Its important pathological process is epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) […]
Changes in DNA methylation of retinal gene promoter regions and their significance in type 1 diabetic rats
Authors: Li Yahong, Geng Chao, Liu Shengnan, Wang Qi, Li Xiaorong, Zhang Yan DOI: 10.3760/cma.j.cn115985-20190616-00262 Published 2020-04-10 Cite as Chin J Exp Ophthalmol, 2020,38(04): 291-299. Abstract [View PDF] [Read Full Text] Objective To study the methylation level of retinal gene promoter region […]
Epigenetics—the new era of biomedical and ophthalmological research
Authors：He Shikun, Ouyang Sha DOI: 10.3760/cma.j.issn.2095-0160.2016.10.001 Published 2016-10-10 Cite as Chin J Exp Ophthalmol, 2016,34(10): 865-873. Abstract [Download PDF] [Read Full Text] Epigenetics is a researching hot topic of worldwide now.Increasing evidence shows that the pathogenesis of human diseases is not […]
Research progress of DNA methylation in lens development and cataract
Authors: Wang Yong, Guan Huaijin DOI: 10.3760/cma.j.issn.2095-0160.2017.08.017 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 747-751. Abstract [Download PDF] [Read Full Text] Epigenetics is the study of genomic structural modifications that affects gene expression without DNA sequence change.Epigenetic mechanisms for the regulation of gene expression include […]