Authors:Yang Hongli, Zhang Hui, Li Xiaorong Corresponding author: Li Xiaorong, Email:lixiaorong@tmu.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20240303-00061 ABSTRACT Retinitis pigmentosa (RP) is a genetically inherited disorder characterized by the progressive degeneration of photoreceptors and a subsequent decline in visual function. Although various treatments, such as neuroprotective drugs, gene repair or gene therapy, and transplantation of stem cells and their derivatives, have been explored, […]
Category: Current Issue
Research progress on targeted regulation of regulatory T cells in new strategies for dry eye treatment
Authors:Liu Lirui, Xu Wen Corresponding author: Xu Wen, Email:xuwen2003@zju.edu.cn Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20230720-00044 ABSTRACT Dry eye is a multifactorial ocular surface disease characterized by the loss of tear film homeostasis caused by many factors, which is often accompanied by ocular surface discomfort, and the related immune mechanism is involved in its occurrence and development. Regulatory T cells (Tregs) are the […]
Research progress of drug-loaded hydrogel in the treatment of uveitis
Authors:Wang Qimiao, Shan Mengyuan, Wang Yan Corresponding author: Wang Yan, Email:wangyan7143@vip.sina.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20231010-00122 ABSTRACT Uveitis is a potentially blinding ocular inflammatory disease characterized by a prolonged course and a high recurrence rate. The clinical treatment of uveitis is limited by the blood-ocular barrier, which reduces the absorption and bioavailability of topically administered drugs. Frequent administration […]
Fungal corneal ulcer caused by Parengyodontium album: a case report
Authors:Wu Feng, Li Man, Liu Xiaona Corresponding author:Liu Xiaona, Email:liuxiaona128@163.com Published:2026-08-10 DOI:10.3760/cma.j.cn115989-20240501-00121 ABSTRACT This study reported the diagnosis and treatment process of a 74-year-old male patient with left eye fungal corneal ulcer caused by Sidea alba induced by ocular trauma. The patient presented with red eye, ocular pain and blurred vision after left eye trauma, […]
Inhibitory effect and mechanism of SB225002 on NLRP3 inflammasome in retinal vascular endothelial cells under high glucose
Authors:Wang Qing, Zhuang Tongtong, Dong Lijie,Wang Linni Corresponding author:Wang Linni, Email:wln5156@163.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20250609-00190 ABSTRACT Objective To observe the effect and possible mechanism of interleukin (IL)-8 antagonist SB225002 on the activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in monkey retinal vascular endothelial cells (RF/6A cells) under high glucose conditions. Methods The RF/6A cells cultured in vitro were […]
Preventive and protective effects of guanethidine against MRSA endophthalmitis in rabbits
Authors:Liang Qian, Shao Zheng,Fan Zheng, Wang Weina, Huang Yusen Corresponding author:Huang Yusen, Email:huang_yusen@126.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240612-00150 ABSTRACT Objective To establish a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA) endophthalmitis and to investigate the regulatory effects of the sympatholytic agent guanethidine on the inflammatory response in endophthalmitis. Methods Six male New Zealand white rabbits of about 2.5 kg were selected and […]
Cone and retinal microvasculature distribution characteristics with idiopathic epiretinal membrane
Authors:Wu Jiang, Ye Xin, Zhou Xiangpeng, He Shucheng, Shen Yingjiao, Shen Lijun Corresponding author:Shen Lijun, Email:slj@mail.eye.ac.cn Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20250613-00200 ABSTRACT Objective To investigate cone density and retinal microvascular distribution characteristics in idiopathic epiretinal membrane (IERM) by utilizing multimodal imaging techniques. Methods A self-controlled study was conducted. Twenty-eight patients (56 eyes) with unilateral IERM diagnosed at the Department of […]
Imaging and clinical characteristics of combined central retinal artery and vein occlusion
Authors:Xie Ting, Li Zhi, Cheng Xiaorong, Wang Weiqing, Li Jin, Liang Siying, Li Wangting, Chen Qingshan Corresponding author:Chen Qingshan, Email:cqs1967@sina.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240821-00239 ABSTRACT Objective To analyze the clinical and imaging features of combined central retinal artery and vein occlusion (CCRAVO) and analyze the correlation with visual acuity improvement. Methods An observational case series study was conducted. Fifteen […]
Clinical observation of anti-VEGF therapy for neovascular age-related macular degeneration combined with cataract after surgery
Authors:Wang Qian, Wang Haiyan, Zhang Lei, Ren Yuecong, Yan Hong Corresponding author:Yan Hong, Email:yan2128ts@hotmail.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20250120-00017 ABSTRACT Objective Based on the new classification of macular neovascularization (MNV), to observe the treatment characteristics of anti-vascular endothelial growth factor (VEGF) in patients with neovascular age-related macular degeneration (nAMD) complicated with cataracts after phacoemulsification. Methods A retrospective cohort study was […]
Retinal thickness and optic disc parameters in children with unilateral and bilateral amblyopia
Authors:Zhu Xixi, Zheng Qiaolan, Chen Jie, Chen Wuhe Corresponding author:Chen Wuhe, Email:cwh@eye.ac.cn Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20241126-00323 ABSTRACT Objective To investigate the differences in retinal layer thickness and optic disc parameters in children with unilateral and bilateral amblyopia. Methods A cross-sectional study was conducted. Seventy-nine amblyopic children who were admitted to the Eye Hospital of Wenzhou Medical University from July […]