Authors: Gong Wei, Liu Kun, He Xiangui
DOI: 10.3760/cma.j.cn115989-20210330-00221
Published 2023-09-10
Cite as Chin J Exp Ophthalmol, 2023, 41(9): 939-943.
Abstract 【Download PDF】 【Read Full Text】
Myopia has become a serious public health problem, but its pathogenesis is still unclear, and effective interventions are relatively scarce.It is recognized that myopia is influenced by both genetic and environmental factors, in which epigenetics may play a key role.Epigenetics refers to the changes in gene expression and function that do not involve DNA sequence variation.Mainly including DNA methylation, non-coding RNA (microRNA, long non-coding RNA and circular RNA, etc.), histone modification and mRNA modification, epigenetic modifications interact to form a complex regulatory network in the pathophysiological process of myopia.By controlling the process of scleral matrix remodeling, eye cell proliferation and retinal development, the morphological characteristics of the eye are jointly regulated, ultimately affecting the onset and development of myopia.Epigenetics has provided new targets of myopia intervention and has become a hotspot in the field.In this paper, we reviewed the current findings of myopia epigenetics to provide a reference for related research.
Key words:
Myopia; Epigenetics; DNA methylation; Non-coding RNA; Histone modification
Contributor Information
Gong Wei
Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center &
Shanghai Children Myopia Institute, Shanghai 200050, China
Liu Kun
Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai 200080, China
He Xiangui
Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center &
Shanghai Children Myopia Institute, Shanghai 200050, China
Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai 200080, China