New understandings of the pathogenesis of primary angle-closure glaucoma

Authors: Ma Mingli,  Sun Jingbo,  Yuan Huiping
DOI: 10.3760/cma.j.cn115989-20200812-00586
Published 2023-02-10
Cite as Chin J Exp Ophthalmol, 2023, 41(2): 188-191.

Abstract                              [Download PDF] [Read Full Text]

Primary angle-closure glaucoma (PACG) is still one of the common blinding eye diseases in China.Because of the irreversibility of the vision loss it caused, the factors affecting the early development of glaucoma are of great concern.The understanding of static anatomic structure of high-risk anterior segment, such as shallow anterior chamber, short axial length, thick iris and large anterior lens cannot fully explain the transformation process of PACG, so the specific role of dynamic changes in the development of glaucoma should be further considered.This article expounded the differences in iris volume and dynamic process of elasticity between normal people and patients with PACG, the incoordination between lens and intraocular structure during eyeball development, the dynamic block and expansion of ciliary body, vitreous and choroid, and the latest research on the relationship between the abnormal ocular nerve and vascular system adjustment and change with the onset of PACG, in order to provide guidance for understanding the pathogenesis of PACG, accurate clinical diagnosis and formulation of treatment strategies.

Key words:

Glaucoma, angle-closure; Iris; Lens, crystalline; Ciliary body; Choroid; Dynamic change; Pathogenic factors; Primary angle closure suspect

Contributor Information

Ma Mingli

Department of Ophthalmology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Sun Jingbo

Department of Ophthalmology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Yuan Huiping

Department of Ophthalmology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, China

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