Research progress of cellular senescence in glaucoma

Authors: Ding Jianfeng,  Li Lu
DOI: 10.3760/cma.j.cn115989-20200604-00394
Published 2023-02-10
Cite as Chin J Exp Ophthalmol, 2023, 41(2): 183-187.

Abstract                                [Download PDF] [Read Full Text]

Cellular senescence is a response process in which cells are activated by ischemia, hypoxia, oxidative stress, DNA damage, reactive oxygen species deposition and other stimulations.Senescent cells markers include such as senescence-associated β-galactosidase (SA-β-gal) activation, P16INK4a upregualtion, senescence-associated heterochromatic foci (SAHF) accumulation, senescence-associated secretory phenotype (SASP) generation, telomere shortening and so on.P16INK4a/Rb and P19ARF/P53/P21Cip1 pathways are two classic cell senescence signaling pathways, which are interconnected and independent on each other.In recent years, glaucoma is considered as a blinding eye disease associated with cell senescence.Research on cell senescence in glaucoma mainly focuses on trabecular meshwork and Schlemm cannel endothelial cells senescence leading to increased resistance of aqueous humor outflow pathway, and the mechanism of retinal ganglion cells senescence and treatment in glaucoma.As an irreversible stage before cell death, deeper study on the mechanism of retinal ganglion cells senescence, and specific blocking of cell senescence will provide a new target for reducing the aqueous humor outflow resistance and protecting the optic nerve in glaucoma.This article reviewed characteristics, inducements, molecular signaling pathways of cellular senescence in glaucoma.

Key words:

Cellular senescence; Glaucoma; Aqueous humor; Retinal ganglion cell

Contributor Information

Ding Jianfeng

Department of Ophthalmology, Wuxi Eighth People’s Hospital, Wuxi 214000, China

Li Lu

Department of Ophthalmology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi 832008, China

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