Regulation of the non-image-forming visual circuit on physiological activity and behavior

Authors: Yuan Man,  Shen Yin
DOI: 10.3760/cma.j.cn115989-20201222-00859
Published 2023-02-10
Cite as Chin J Exp Ophthalmol, 2023, 41(2): 192-195.

Abstract                              [Download PDF] [Read Full Text]

Retinal ganglion cells (RGCs) are final output neurons from the retina to the brain, which can transmit light signals and participate in image-forming vision (IFV) (image formation) and non-image-forming vision (NIFV) (non-image formation). Visual processing system not only transmits visual information of images, but also influences human physiological activities and behaviors by incoming optical signals, which is called NIFV.NIFV relies less on signals generated by conventional photoreceptor cells, but a special class of intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs are a subset of retinal ganglion cells that express melanopsin.The axons of the ipRGCs project to unique targets and modulate a broad range of NIFV behaviors, from basic physiological regulation (such as heart rate and pupil size) to more complex behavioral regulation (such as circadian rhythm) and even higher-level cognitive processes (such as anxiety and other emotions). NIFV circuit is an important response to light, and ipRGCs plays a vital role in NIFV circuit.This article reviewed the regulation of NIFV circuit in physiological activities and behaviors, summarized the relationship between the projections of ipRGCs to the NIFV function, and provided ophthalmologists with more knowledge of visual system.

Key words:

Retinal ganglion cells; Visual circuit; Physiological activity; Behavior; Non-image-forming vision

Contributor Information

Yuan Man

Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China

Shen Yin

Eye Center, Renmin Hospital of Wuhan University, Wuhan 430060, China

Medical Research Institute, Wuhan University, Wuhan 430071, China

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