NLRP3 inflammasome and eye diseases

Authors: Zhang Yujian,  Ji Min,  Guan Huaijin

DOI: 10.3760/cma.j.cn115989-20200325-00203
Published 2020-04-10
Cite as Chin J Exp Ophthalmol, 2020,38(04): 365-368.

Abstract

Nucleotide binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a set of intracellular protein complexes.NLRP3 inflammasome can trigger the activation of caspase-1 and contribute to the maturation of interleukin, and finally result in a series of inflammation responses in host.Inflammasomes are activated in a variety of cases, including multiple inflammation-related eye diseases, such as xerophthalmia, glaucoma, age-related macular degeneration and so on.This article aimed to interpret the effect and mechanism of the activation of NLRP3 inflammasome, and reviewed how the mutation of gene or the structure disturbance of protein related to NLRP3 inflammasome affects the occurrence and development of inflammation-related eye diseases.

Key words:

Inflammasomes; Exophthalmia; Glaucoma; Age-related macular degeneration; Diabetic retinopathy

Contributor Information

Zhang Yujian
Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, China
Ji Min
Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, China
Guan Huaijin
Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong 226001, China
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Updated: May 8, 2020 — 3:42 am