Tag: Inflammasomes

Effect of ROS/NLRP3/Caspase-1 signaling pathway on the apoptosis of retinal pigment epithelial cells induced by high glucose

Authors: Li Hongsong,  Li Rong,  Wang Lijun,  Liao Dingying,  Wang Jianming DOI: 10.3760/cma.j.cn115989-20210420-00267-1 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 6-12. Abstract Objective To investigate the effect of the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasome on the proliferation and apoptosis of human retinal pigment epithelial cell line ARPE-19 exposed to […]

NLRP3 inflammasome and its role in age-related macular degeneration

Authors: Chen Lu,  Xie Ping,  Hu Zizhong DOI: 10.3760/cma.j.cn115989-20210922-00527 Published 2022-01-10 Cite as Chin J Exp Ophthalmol, 2022, 40(1): 73-77. Abstract Age-related macular degeneration (AMD), the leading cause of central vision loss among people aged 50 years and older, is one of the major eye diseases causing blindness in the world. Clinically, advanced AMD is […]