Research advances in neuroprotective role of sigma-1 receptor in retina

Authors: Ma Xiaochen,  Liu Hongling
DOI: 10.3760/cma.j.cn115989-20200110-00017
Published 2023-05-10
Cite as Chin J Exp Ophthalmol, 2023, 41(5): 512-515.

Abstract                              [Download PDF] [Read Full Text]

Retinal degenerative diseases are a major contributor to visual impairment worldwide, and research related to retinal degenerative diseases is increasingly becoming a hot topic.The sigma-1 receptor is a 223-amino-acid endoplasmic reticulum transmembrane protein, and its gene sequence is highly conserved throughout mammals.Sigma-1 receptors are widely distributed in various tissues and organs.Numerous studies have proved the protective role of sigma-1 receptors in retinal pathological processes, including anti-oxidative stress, anti-inflammatory response, and anti-apoptosis.In addition, sigma-1 receptors have potential therapeutic roles in retinal diseases, especially diabetic retinopathy, retinitis pigmentosa and glaucomatous neuropathy.In this paper, the molecular mechanisms of sigma-1 receptor-mediated retinal neuroprotection and its application in the treatment of retinal diseases were reviewed.

Key words:

Retina; Sigma-1 receptor; Nerve protection

Contributor Information

Ma Xiaochen

Department of Ophthalmology, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China

Liu Hongling

Department of Ophthalmology, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China

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