Research progress of intervention treatment on the retinal ischemia-reperfusion injury

Authors: Zhang Xue,  Sun Dawei

DOI: 10.3760/cma.j.issn.2095-0160.2017.05.016
Published 2017-05-10
Cite as Chin J Exp Ophthalmol, 2017,35(5): 463-467.

Abstract

Retinal ischemia-reperfusion injury (RIRI) is a common pathological and physiological clinical oculopathy, which can occur in retinal artery and vein occlusion, diabetic retinopathy and acute angle-closure glaucoma.The resulting ischemia can cause cell metabolic dysfunction, serious retinal damage and descending visual function.RIRI is the result of multiple factors.The currently accepted hypotheses mainly include the injury effect of oxygen-derived free radicals, intracellular calcium overload, the action of leucocyte and apoptosis.However the protection and treatment research in the RIRI is limited.The present paper reviews the progression in the drug intervention of RIRI.

Key words:

Retina; Ischemia-reperfusion injury; Intervention treatment

Contributor Information

Zhang Xue
Department of Ophthalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
Sun Dawei
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Updated: September 4, 2019 — 12:51 pm