Role of interleukin in neuromyelitis optica spectrum disorder

Authors: Xu Xintong,  Xu Quangang,  Wei Shihui
DOI: 10.3760/cma.j.cn115989-20200702-00473
Published 2023-11-10
Cite as Chin J Exp Ophthalmol, 2023, 41(11): 1124-1129.

Abstract                            【Download PDF】 【Read Full Text

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system, primarily affecting the optic nerve and spinal cord.In addition to aquaporin 4 antibody, more and more studies have shown that interleukins (IL) also play an important role in the progression of NMOSD.For example, among the most common CD4+ T cells, Th17 cells can destroy the blood-brain barrier to invade the central nervous system and then affect autoimmunity; Th2-mediated IL-4 and IL-10 regulate immune activities by activating macrophages; Tregs can suppress the immune response by restricting various immune cell functions.The levels of related IL in the cerebrospinal fluid and blood of NMOSD patients vary at different stages of the disease course.This article mainly reviews the role and a change characteristics of interleukins related to NMOSD, which helps us to understand its pathogenic mechanism in-depth, and discusses whether IL can be used as immunophysiological markers to diagnose NMOSD.

Key words:

Neuromyelitis optica spectrum disorder; Interleukin; Th17; Th2; Tregs

Contributor Information

Xu Xintong

Medical School of Chinese PLA, Beijing 100853, China

Xu Quangang

The Third Medical Center of the Chinese PLA General Hospital, Beijing 100039, China

Wei Shihui

The First Medical Center of the Chinese PLA General Hospital, Beijing 100853, China

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