Tag: Apoptosis

Research progress on the inhibition of photoreceptor cell apoptosis by the pentose phosphate pathway and its molecular mechanism

Authors: Han Siyang,  Sun Xiaodong DOI: 10.3760/cma.j.cn115989-20210317-00179 Published 2024-01-10 Cite as Chin J Exp Ophthalmol, 2024, 42(1): 72-75. Abstract                              [Download PDF] [Read Full Text] Photoreceptor cells are a special type of neuroepithelial cells, which play an important role in the generation and […]

Inhibitory effect of specnuezhenide on high glucose-induced human retinal microvascular endothelial cell injury and its mechanism

Authors: Liu Qian,  Feng Xiaomei,  Liu Changgeng,  Li Haijun,  Yang Xiaoyuan,  Ren Jing,  Zhang Ying DOI: 10.3760/cma.j.cn115989-20211130-00662 Published 2023-04-10 Cite as Chin J Exp Ophthalmol, 2023, 41(4): 312-320. Abstract                              [Download PDF] [Read Full Text] Objective To investigate the effect of specnuezhenide on […]

Antagonistic effect of SC79 on high glucose-induced apoptosis of RPE cells and its regulatory mechanism on AKT-XIAP signaling pathway

Authors: Zheng Lei,  Ma Dahui,  Chen Miaohong,  Zhang Guoming DOI: 10.3760/cma.j.cn115989-20210710-00405 Published 2023-03-10 Cite as Chin J Exp Ophthalmol, 2023, 41(3): 226-232. Abstract                               [Download PDF]  [Read Full Text] Objective To investigate the antagonistic effect and potential mechanism of specific AKT activator SC79 […]

Promoting effect of AGTR1 blocker olmesartan on the apoptosis of HTF and its mechanism

Authors: Wang Lijun,  Li Hongsong,  Zhang Wenyi,  Shao Meilin,  Ren Meimei,  Wang Jianming DOI: 10.3760/cma.j.cn115989-20220601-00262 Published 2023-02-10 Cite as Chin J Exp Ophthalmol, 2023, 41(2): 119-126. Abstract                            [Download PDF] [Read Full Text] Objective To study the effect and mechanism of angiotensin type 1 […]

Inhibitory effects of N-acetylcysteine and salubrinal on apoptosis of retinal pigment epithelial cells induced by all-trans-retinoic acid

Authors: Wu Juan,  Cui Dongmei,  Zeng Junwen DOI: 10.3760/cma.j.cn115989-20200414-00262 Published 2023-01-10 Cite as Chin J Exp Ophthalmol, 2023, 41(1): 16-21. Abstract                                    [Download PDF] [Read Full Text] Objective To observe the effect of the antioxidant N-acetylcysteine (NAC) and selective endoplasmic […]

Protective effect of tert-butylhydroquinone on retinal morphology and function in early diabetic rats and its mechanism

·Experimental Research· Protective effects of tert-butylhydroquinone on retinal structure, function and mechanism in early diabetic rat models Wang Juan1, Wei Fang2, Cao Yang1, Tian Min1, Lyu Hongbin1 1Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; 2Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, […]

Inhibitory effect of microRNA-23b-3p on high glucose-induced autophagy and apoptosis of human lens epithelial cells and its mechanism

·Experimental Research· Role and mechanism of microRNA-23b-3p in regulating high glucose-induced autophagy and apoptosis of human lens epithelial cells Liu Wenlan, Wang Li, Yang Yang, Yan Jin School of Medical Technology, Xi’an Medical University, Xi’an 710021, China Corresponding author: Wang Li, Email: 63148645@qq.com [Abstract]                        […]

Protective effect of myricitrin on retinal microvascular endothelial cells induced by high glucose and its regulation mechanism

·Experimental Research· Protective effect of myricitrin on retinal microvascular endothelial cells induced by high glucose and its regulation mechanism Liu Qian, Liu Changgeng, Li Haijun, Dong Yangzeng, Zhang Ying Department of Ophthalmology, Henan Provincial People’s Hospital, People’ s Hospital of Zhengzhou University, Henan Eye Hospital, Henan Eye Institute, Zhengzhou 450003, China Corresponding author: Liu Qian, […]

Inhibitory effect of siRNA-KCNQ1OT1 on human lens epithelial cell apoptosis by targeting miR-199a-5p

Authors: Lu Cheng,  Zhang Fengyan,  Zhang Yuhang,  Zhang Jiajuan DOI: 10.3760/cma.j.cn115989-20210427-00280 Published 2022-06-10 Cite asChin J Exp Ophthalmol, 2022, 40(6): 514-523. Abstract                              [View PDF]  [Read Full Text] Objective To explore the inhibitory effect of long non-coding RNA (lncRNA) KCNQ1 overlapping transcript […]

Regulation of miR-155 in H2O2-induced oxidative stress in lens epithelial cells via targeting SIRT1

Authors: Niu Yantao,  Zhang Li,  Xie Wenfang DOI: 10.3760/cma.j.cn115989-20201104-00735 Published 2022-05-10 Cite asChin J Exp Ophthalmol, 2022, 40(5): 404-413. Abstract                              [View PDF] [Read Full Text] Objective To investigate the role of microRNA (miR)-155 in hydrogen peroxide (H2O2)-induced oxidative stress injury in lens epithelial cells (LECs) […]