Tag: Apoptosis

Regulation of miR-155 in H2O2-induced oxidative stress in lens epithelial cells via targeting SIRT1

Authors: Niu Yantao,  Zhang Li,  Xie Wenfang DOI: 10.3760/cma.j.cn115989-20201104-00735 Published 2022-05-10 Cite asChin J Exp Ophthalmol, 2022, 40(5): 404-413. Abstract Objective To investigate the role of microRNA (miR)-155 in hydrogen peroxide (H2O2)-induced oxidative stress injury in lens epithelial cells (LECs) and its mechanism regulating silent information regulator factor related enzymes 1 (SIRT1). Methods The HLE-B3 […]

Promoting effect of miR-15a on high glucose-induced oxidative stress in human lens epithelial cells and its mechanism

Authors: Nan Anchao,  Nan Jianru,  Liu Yadong,  Liu Xiangling DOI: 10.3760/cma.j.cn115989-20200301-00126 Published 2022-05-10 Cite asChin J Exp Ophthalmol, 2022, 40(5): 422-430. Abstract Objective To investigate the effect of microRNA-15a (miR-15a) on the anti-oxidative stress ability of human lens epithelial cells (LECs) induced by high glucose and its possible mechanism. Methods The anterior lens capsule specimens […]

Inhibitory effect of CLC-2 chloride channel targeted blocking on fibrosis of human conjunctival fibroblasts

Authors: Wu Sharengaowa,  Cui Renzhe,  Lu Di,  Ding Haoxuan,  Sun Lixia DOI: 10.3760/cma.j.cn115989-20200609-00410 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 294-302. Abstract Objective To investigate the inhibitory effect of CLC-2 chloride channel targeted blocking on fibrosis of human conjunctival fibroblasts (HConF). Methods HConF were divided into blank control group, lipofectamine 2000 (Lipo2000) group, […]

Effect of human umbilical cord derived mesenchymal stem cells on apoptosis of rat retinal ganglion cells under high glucose and on the regulation of p38MAPK pathway

Authors: Liu Xi,  Sun Xiaoping,  Yang Jianwei,  Zhu Dongmei,  Wang Yuan DOI: 10.3760/cma.j.cn115989-20200804-00559 Published 2022-01-10 Cite asChin J Exp Ophthalmol, 2022, 40(1): 21-28. Abstract Objective To investigate the effect of human umbilical cord mesenchymal stem cells (hUC-MSC) on the apoptosis of retinal ganglion cells (RGCs) in diabetic retinopathy (DR) model rats and on the regulation […]