Research progress and prospect of metabonomics in glaucoma

Authors: Lu Yunqing,  Zhong Hua
DOI: 10.3760/cma.j.cn115989-20200808-00572
Published 2023-02-10
Cite as Chin J Exp Ophthalmol, 2023, 41(2): 178-182.

Abstract                              [Download PDF] [Read Full Text]

Metabonomics is an important component of systems biology.It reveals the essential metabolic characteristics of the activities of organisms using qualitative and quantitative detection and analysis of the dynamics of all endogenous low-molecular-weight metabolites within an organism before and after stimulation such as pathophysiological stimuli or genetic modification.Therefore, it provides insight into the pathogenesis, early diagnosis, treatment and prognosis of diseases.Metabonomics relies on chromatography, mass spectrometry, nuclear magnetic resonance spectroscopy and other analytical chemistry techniques to obtain data.The examination specimens are usually body fluids including blood, tear, aqueous humor and tissues such as trabecular meshwork, vitreous body, retina, etc.Glaucoma is an optic nerve disease characterized by optic disc damage and visual field defect.Previous animal and human studies have provided some preliminary results on metabolites associated with glaucoma.Metabonomics, genomics, transcriptomics, and proteomics constitute a bioinformatics system.Joint multi-omics research will be the direction of future development.On the basis of an overview of metabonomics, this paper reviewed the research progress of metabonomics in glaucoma based on different tissues and body fluid specimens.

Key words:

Glaucoma; Metabonomics; Aqueous humor; Mass spectrometry

Contributor Information

Lu Yunqing

Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

Zhong Hua

Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

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