Research progress of intracameral moxifloxacin in the prevention of bacterial endophthalmitis after cataract surgery

Authors: Yan Weijia,  Zhou Haiyan,  Yan Hong
DOI: 10.3760/cma.j.cn115989-20210304-00146
Published 2022-05-10
Cite asChin J Exp Ophthalmol, 2022, 40(5): 461-465.

Abstract

Postoperative endophthalmitis (POE) is a serious vision-threatening complication of cataract surgery, with an incidence rate of 0.033%-0.11% in China.In recent years, numerous retrospective studies and data analyses have reported that intracameral injection of antibiotics can effectively reduce the incidence of bacterial endophthalmitis, which commonly include cefuroxime, vancomycin and moxifloxacin.Globally, due to factors such as the availability, cost-effectiveness, and types of pathogens of POE, the drug choice varies to a large extent.Adverse events caused by antibiotics in the intracameral injection often occur, including macular edema, retinal vascular leakage, and uveitis caused by overdose of cefuroxime, and complications such as hemorrhagic retinal vasculitis obliterans due to vancomycin.Moxifloxacin, as a fourth-generation fluoroquinolone, has a significant effect on the prevention of bacterial endophthalmitis.Studies in the past five years related to moxifloxacin, and the significant advantages of moxifloxacin in the prevention of bacterial endophthalmitis, drug safety, duration of intracameral drug, and cost-effectiveness were summarized in this article.

Key words:

Injections, anterior chamber; Endophthalmitis, bacterial; Cataract, postoperative; Moxifloxacin; Cefuroxime; Vancomycin

Contributor Information

Yan Weijia

Xi’an People’s Hospital (Xi’an Fourth Hospital), Shaanxi Eye Hospital, Affiliated Guangren Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710004, China

Zhou Haiyan

Department of Ophthalmology, Shaanxi Provincial People’s Hospital, Xi’an 710068, China

Yan Hong

Xi’an People’s Hospital (Xi’an Fourth Hospital), Shaanxi Eye Hospital, Affiliated Guangren Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an 710004, China

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