Critical guiding role of OCT angiography in long-term treatment and follow-up of neovascular AMD

Authors: Bo Qiyu,  Sun Xiaodong
DOI: 10.3760/cma.j.cn115989-20220617-00282
Published 2022-07-10
Cite asChin J Exp Ophthalmol, 2022, 40(7): 604-608.

Abstract

The pathogenesis of neovascular age-related macular degeneration (nAMD) is complex and macular neovascularization (MNV), a key pathogenic factor in nAMD, is prone to recurrence.Vitreous injection of anti-VEGF drugs is the main therapy of nAMD.In recent years, a lot of progress has been made in fundus imaging techniques and optical coherence tomography angiography (OCTA) with non-invasive, rapid, stratified and high-definition functions has shown strong advantages in diagnosis, differential diagnosis, disease dynamic monitoring and follow-up of nAMD.Clinicians have had a certain understanding of the important role of OCTA in the diagnosis of nAMD and other diseases, and its clinical application value has been recognized gradually.However, its application value in follow-up of patients with nAMD and polypoid choroidal vasculopathy (PCV) is still not well understood.By reviewing a large number of recent relevant literature on OCTA, and combining the clinical practice of our research team in monitoring the course of AMD and PCV disease by OCTA, we have gained new knowledge and understanding of the pathological mechanism of AMD and PCV.In this paper, we elucidated the latest understanding of the diagnostic value of OCTA in AMD based on long-term series of OCTA studies, the new findings of OCTA in AMD management of our team, as well as its impact on ophthalmology clinical practice.Then we forecasted the role of OCTA in the prediction of recurrence and anti-VEGF treatment response, as well as the clinical value of OCTA in the optimization of nAMD treatment and follow-up plan.It is recommended that clinicians pay more attention to the clinical value and guiding role of OCTA in long-term treatment monitoring and follow-up of AMD.

Key words:

Tomography, optical coherence; Aged; Macular degeneration/diagnosis; Choroidal neovascularization/diagnosis; Exudates and transudates; Predictive value of tests; Vascular endothelial growth factor/antagonists & inhibitors; Optical coherence tomography angiography

Contributor Information

Bo Qiyu

National Clinical Research Center for Ophthalmic Diseases, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China

Sun Xiaodong

National Clinical Research Center for Ophthalmic Diseases, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China

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