·Experimental Research· Establishment of a lens opacity model in Grx2 knockout mice based on the CRISPR/cas9 system and the role of Grx2 in cataract pathogenesis Guo Yong1, Guo Chenjun2, Zhang Jie2, Ning Xiaona2, Chen Xi3, Yan Hong1 1Department of Ophthalmology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Shaanxi Eye Hospital, Xi’an 710004, China; 2Department of Ophthalmology, […]
Tag: Oxidative damage
Inhibitory effect of melatonin on pyroptosis of lens epithelium cells and its mechanism
Authors: Yang Xin, Liu Xuhui, Meng Jia, Fang Mengyuan, Zhang Fengyan DOI: 10.3760/cma.j.cn115989-20210516-00307 Published 2022-05-10 Cite asChin J Exp Ophthalmol, 2022, 40(5): 414-421. Abstract [View PDF] [Read Full Text] Objective To investigate the inhibitory effect of melatonin on pyroptosis of lens epithelium cells (HLECs) induced […]
Protective effect and mechanism of esculetin on oxidative damaged ARPE-19 cells
Authors: Zhang Yingjun, Bai Ge, He Xiangdong, Zhang Donglei, He Wei DOI: 10.3760/cma.j.cn115989-20200224-00101 Published 2020-12-10 Cite as Chin J Exp Ophthalmol, 2020,38(12): 1025-1031. Abstract [View PDF] [Read Full Text] Objective To study the protective effect and the mechanism of esculetin on oxidative-stressed human retinal pigment […]
Anti-oxydative effects of miR-204 on LECs in age-related cataract
Authors: Su Xianhua, Wang Ye, Huang Yusen DOI: 10.3760/cma.j.issn.2095-0160.2016.03.008 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 227-233. Abstract [Download PDF] [Read Full Text] Background miRNAs are a group of non-coding small RNA molecules, and they play an important role in regulating the apoptosis of LECs.The biological effects […]