Authors: Wei Xing, Sui Ruifang DOI: 10.3760/cma.j.cn115989-20200627-00457 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 737-742. Abstract [View PDF] [Read Full Text] Inherited retinal degeneration (IRD), a group of diseases often causing irreversible blindness, with multiple pathogenesis, still lacks effective treatments currently.Development of effective […]
Tag: Gene therapy
Related clinical trials and prospects of gene therapy for neovascular age-related macular degeneration
Authors: Zhang Wei, Yan Hua DOI: 10.3760/cma.j.cn115989-20210113-00033 Published 2021-08-10 Cite asChin J Exp Ophthalmol, 2021, 39(8): 749-754. Abstract [View PDF] [Read Full Text] Neovascular macular degeneration (nAMD) is one of the main eye diseases causing blindness in the elderly population.Early detection and early treatment are […]
Gene therapy for retinal diseases: global progress and challenges
Author: Wu Zhijian DOI: 10.3760/cma.j.cn115989-20200716-00500 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 633-638. Abstract [View PDF] [Read Full Text] In the past three decades, we have witnessed the great promise of gene therapy in treating a variety of inherited and acquired retinal diseases. The […]
Advances of genetics of age-related macular degeneration
Authors: Xu Jingjing, Hu Yuntao DOI: 10.3760/cma.j.cn115989-20200509-00324 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 715-720. Abstract [View PDF] [Read Full Text] Age-related macular degeneration (AMD) is one of the leading causes of blindness for the elderly over 50, characterized by loss of central vision […]
Tropisms of rAAV2, 6, 8, 9 serotypes for intravitreal injection in the mouse retina
Authors: Li Taiming, Wei Zheng, Liu Xiaomei, Shao Jiahong, Yuan Yun, Cao Jinjing, Wang Feifei, Wang Dongxin, Li Wensheng, Zhang Chun DOI: 10.3760/cma.j.cn115989-20200326-00210 Published 2020-05-10 Cite as Chin J Exp Ophthalmol, 2020,38(05): 381-387. Abstract [View PDF] [Read Full Text] Objective To compare the tropism of different […]
Focus on the treatment of inherited retinal diseases
Author:Pang Jijing DOI: 10.3760/cma.j.issn.2095-0160.2019.09.001 Published 2019-09-10 Cite as Chin J Exp Ophthalmol, 2019,37(9): 689-693. Abstract [View PDF] [Read Full Text] Inherited retinal diseases (IRDs) are rare and incurable eye diseases.Gene therapy has become a new method for the treatment of IRDs.At present, at least 26 clinical […]
Advance in gene therapy of ocular disease
Authors：Lyu Juling, Xing Yiqiao, Shen Yin DOI: 10.3760/cma.j.issn.2095-0160.2016.10.019 Published 2016-10-10 Cite as Chin J Exp Ophthalmol, 2016,34(10): 952-956. Abstract [Download PDF] [Read Full Text] Currently, 31 clinical trials have been approved, most of them are still in progress.Leber congenital amaurosis (LCA) has been conducted to phase […]
Research progress in neuroregeneration of traumatic optic neuropathy
Authors: Chen Haiying, Huang Zhengru DOI: 10.3760/cma.j.issn.2095-0160.2018.01.016 Published 2018-01-10 Cite as Chin J Exp Ophthalmol, 2018,36(1): 75-80. Abstract [Download PDF] [Read Full Text] Traumatic optic neuropathy (TON) is commonly associated with blunt ocular trauma and craniofacial injuries, leading irreversible visual impairment.Like other mammalian […]
Application of CRISPR/Cas9 genome editing technology in the research of eye diseases
Authors: Fan Xiangyu, Xu Jianjiang DOI: 10.3760/cma.j.issn.2095-0160.2018.07.015 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 553-558. Abstract [Download PDF] [Read Full Text] The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is an adaptive immune system against invasive viruses and exogenous DNA, which is developed […]
Studies on pathogenesis and gene therapy of red-green color blindness
Authors: Xu Fan, Pang Jijing DOI: 10.3760/cma.j.issn.2095-0160.2018.07.014 Published 2018-07-10 Cite as Chin J Exp Ophthalmol, 2018,36(7): 549-552. Abstract [Download PDF] [Read Full Text] Red-green color blindness is the most common form of colour blindness.Traditional treatment options such as tinted lenses do not cure color blindness completely.With the […]