Category: 2017, No. 08

Research progress on correlation between microRNA and retinal development

Authors: Liu Xiaochen,  Wu Min DOI: 10.3760/cma.j.issn.2095-0160.2017.08.021 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 764-768. Abstract MicroRNAs (miRNAs) are small, stable RNA molecules that post-transcriptionally regulate gene expression in plants and animals by base pairing to partially complementary sequences on target mRNAs to inhibit protein synthesis.More than 200 miRNAs are reportedly expressed in the retina, […]

Research progress of miR-204 in the regulation of ophthalmic diseases

Authors: Xu Yanying,  Mao Xinbang DOI: 10.3760/cma.j.issn.2095-0160.2017.08.020 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 761-763. Abstract MicroRNAs (miRNAs) are endogenous short nucleotide non-coding RNAs which widely exist in eukaryotic organisms, involved in the body’s life process, including cell growth, differentiation, proliferation, apoptosis and autophagy.MiR-204-5p is located on chromosome TRPM3 in the 9q21.12 large intron 6 […]

Gene research progress of retinoblastoma

Authors: Yu Tian,  Chen Changzheng,  Xing Yiqiao DOI: 10.3760/cma.j.issn.2095-0160.2017.08.019 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 756-760. Abstract Retinoblastoma (RB) is a common intraocular malignant tumor of infants.It not only seriously threats children’s eyesight, but also endangers their lives.RB develops from the immature cells of retina and its occurrence is closely related with the tumor suppressor […]

Update on mutations of precursor mRNA splicing factor genes linked to retinitis pigmentosa

Authors: Xia Weiyi,  Zhao Chen DOI: 10.3760/cma.j.issn.2095-0160.2017.08.018 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 752-755. Abstract Retinitis pigmentosa (RP), one of the common forms of hereditary retinal dystrophies (HRD), is typified by significant genetic heterogeneities.Executed by the spliceosome, precursor mRNA (pre-mRNA) splicing is a highly regulated process by which introns are removed and exons are […]

Research progress of DNA methylation in lens development and cataract

Authors: Wang Yong,  Guan Huaijin DOI: 10.3760/cma.j.issn.2095-0160.2017.08.017 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 747-751. Abstract Epigenetics is the study of genomic structural modifications that affects gene expression without DNA sequence change.Epigenetic mechanisms for the regulation of gene expression include DNA methylation, histone modifications, and microRNAs.DNA methylation may contribute to silencing gene expression which is […]

Survey of medical resources of eye care in Tibet autonomous region

Authors: Dan Zengrenqing,  Li Xiaoxin,  Tsedenyangkyi null DOI: 10.3760/cma.j.issn.2095-0160.2017.08.016 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 743-746. Abstract Background The improvement of the eye care system has being a strong guarantee for blindness prevention.However, medical resources of eye care in Tibet autonomous region cannot jet meet the effective requirement.Knowing the present situation of medical resources of […]

Associations of single nucleotide polymorphisms of UCP genes with diabetic retinopathy in Chinese Han population

Authors: Jin Peiyao,  Li Zhiqiang,  Xu Xian,  He Jiangnan,  Chen Jianhua,  Xu Xun,  Du Xuan,  Bai Xuelin,  Zhang Bo,  He Xiangui,  Lu Lina,  Zhu Jianfeng,  Shi Yongyong,  Zou Haidong DOI: 10.3760/cma.j.issn.2095-0160.2017.08.015 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 737-742. Abstract Background Researches showed that elevatory blood glucose level results in long-term damage of cells and tissue, or metabolic memory phenomenon, and manipulation of hyperglycemic memory is a […]

Affecting factors of corneal epithelial healing following de-epithelized corneal collagen cross linking in keratoconus patients

Authors: Huang Xiaojing,  Shi Peiyan,  Jiang Yin,  Zhao Can,  Sun Jijun,  Wang Ting DOI: 10.3760/cma.j.issn.2095-0160.2017.08.014 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 732-736. Abstract Background Corneal collagen cross-linking (CXL) shows good clinical effects for keratoconus, and de-epithelized CXL appears to be benefit to the distribution and absorption of riboflavin in cornea stroma.However, de-epithelization of CXL will increase the infective […]

Clinical characteristic and management of Peters anomaly

Authors: Liang Tianwei,  Zhang Chengyue,  Zhang Yan,  Li Cheng,  Li Li,  Wu Qian,  Zhao Junyang DOI: 10.3760/cma.j.issn.2095-0160.2017.08.013 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 727-731. Abstract Background Peters anomaly is a rare eye disease.Understanding the clinical features of Peters anomaly is helpful for us to correctly manage this disease. Objective This study was to investigate the clinical characteristics and treatment […]

Genetic analysis of a Chinese family with congenital aniridia and detection of PAX6 mutation locus

Authors: Zhang Luxi,  Yang Ge,  Jia Jing,  Wan Wencui,  Yang Xin,  Jin Xuemin DOI: 10.3760/cma.j.issn.2095-0160.2017.08.011 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 721-725. Abstract Background Congenital aniridia is a rare bilateral hereditary ophthalmopathy which impact panocular.Researches showed that congenital aniridia can be caused by different mutation locus of PAX6 genes, and the mutations are multifarious. Objective This study was […]