Category: 2016

Influence factors and strategies of anti-VEGF therapy for wet AMD

Authors: Dai Hong,  Lu Yingyi DOI: 10.3760/cma.j.issn.2095-0160.2016.01.001 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 1-4. Abstract Neovascular age-related macular degeneration is also known as wet age-related macular degeneration (wAMD), which is now one of potentially blinding diseases in elder population worldwide.The application of anti-vascular endothelial growth factor (VEGF) drugs is becoming the first-line therapy for […]

RP research in the era of precision medicine: discovery to translation

Authors: Yang Jing,  Xiaowu Gai,  Eric Pierce DOI: 10.3760/cma.j.issn.2095-0160.2016.01.002 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 5-10. Abstract Retinitis pigmentosa (RP) encompasses many different hereditary retinal degenerations that are caused by a vast array of different gene mutations and have highly variable disease presentations and severities.Work over the past 25 years has resulted in the identification […]

Inhibition of PTB-associated splicing factor on IGF-1/VEGF signaling pathway in retinal vascular endothelial cells

Authors: Tian Fang,  Dong Lijie,  Ji jie,  Zhou Yu,  Li Wenbo,  Bai Lingling,  Wang Fei,  Qi Chen,  Su Chang,  Zhang Xiaomin,  Li Xiaorong  DOI: 10.3760/cma.j.issn.2095-0160.2016.01.003 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 11-16. Abstract Background Retinal neovascularization (RNV) is common findings of many fundus diseases.Research showed that insulin-like growth factor-1 (IGF-1) induces the proliferation of vascular endothelial cells and therefore promotes the formation of […]

Promoting effect of p75NTR receptor overexpression on oxidative stress injury in human retinal pigment epithelium cells

Authors: Qi Yun,  Bai Yujing,  Li Xiaoxin,  Shi Xuan DOI: 10.3760/cma.j.issn.2095-0160.2016.01.004 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 17-23. Abstract Background Choroidal neovascularization (CNV) is the primary pathogenic cause of many fundus diseases.Oxidative stress injury of retinal pigment epithelial (RPE) cells plays important role in angiogenesis of choroid new blood vessels.Oxidative stress injury can active p75NTR receptor, […]

Inhibition of CCN1 siRNA on retinal endothelial cells

Authors: Di Yu,  Zhang Yiou,  Wang Aiyuan,  Chen Xiaolong DOI: 10.3760/cma.j.issn.2095-0160.2016.01.005 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 24-29. Abstract Background Cysteine-rich 61(Cyr61)/CCN1 has been reported to stimulate retinal neovascularization (RNV) in retinopathy of prematurity (ROP). However, whether CCN1 small interfering RNA (CCN1 siRNA) can inhibit or cure ROP has not been extensively investigated. Objective This study […]

Inhibition of ADP-ribosylation factor antagonist on human retinal vascular endothelial cell tube formation in vitro

Authors: Wu Jing,  Liu Gaoqin,  Chen Zhigang,  Xiao Yanhui,  Xu Jing,  Lu Peirong DOI: 10.3760/cma.j.issn.2095-0160.2016.01.006 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 30-34. Abstract Background Researches showed that ADP-ribosylation factor (ARF) promotes intracorneal secretion of multiple angiogenesis-related factors, such as vascular endothelial growth factor (VEGF) and nitricoxide synthase (NOS) etc., and therefore results in corneal neovascularization.However, whether ARF affects […]

The protactive effects and mechanisms of cx3cr1 antibody on retinal neuron in rats with ischemia reperfusion injury by intravitreal injection

Authors: Li Juanjuan,  Li Yan,  Tang Zhiwei  DOI: 10.3760/cma.j.issn.2095-0160.2016.01.007 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 35-41. Abstract Background Study confirmed that the active microglia may injure retinal ganglion cells (RGCs) in retinal ischemia reperfusion injury (IRI), and increased cx3cr1 expression is an important factor in microglial activation, and thus blocking the expression of cx3cr1 can […]

Induce and differentiation of pig Müller cells into photoreceptors in vitro

Authors: Xu Ni,  Liu Yongqing,  Douglas C Dean,  Dong Fangtian DOI: 10.3760/cma.j.issn.2095-0160.2016.01.009 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 43-48. Abstract Background Recent studies indicated that rat and mouse Müller cells can be induced and differentiated into photoreceptor-like cells in vitro, but it is not known whether this also happens to adult pig Müller cells nowadays. Objective […]

Contrast of retinal structure and function developing of premature rats versus full-term newborn rats

Authors: Yang Xiangmin,  Li Rong,  Wang Yusheng,  Su Jingbo,  An Jing,  Chen Tao,  Cao Qinglin,  Zhang Zuoming DOI: 10.3760/cma.j.issn.2095-0160.2016.01.010 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 49-55. Abstract Background Premature birth is a high risk factor of abnormal development in the morphology and function of vision system.To observe the effect of premature birth on the structural and functional development of neonatal […]

Expression changes of brain-derived neurotrophic factor in retina of oxygen-induced retinopathy

Authors: Duan Haixia,  Guo Kai,  Wang Banwei DOI: 10.3760/cma.j.issn.2095-0160.2016.01.011 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 56-59. Abstract Background Neovascular diseases such as retinopathy of prematurity often leads to irreversible vision loss.The study on oxidative damage mechanism is becoming more and more important.Whether brain derived neurotrophic factor (BNDF) has protection to retinal ganglion cells(RGCs) has few […]