Authors:Wang Qing, Zhuang Tongtong, Dong Lijie,Wang Linni Corresponding author:Wang Linni, Email:wln5156@163.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20250609-00190 ABSTRACT Objective To observe the effect and possible mechanism of interleukin (IL)-8 antagonist SB225002 on the activation of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in monkey retinal vascular endothelial cells (RF/6A cells) under high glucose conditions. Methods The RF/6A cells cultured in vitro were […]
Category: Current Issue
Preventive and protective effects of guanethidine against MRSA endophthalmitis in rabbits
Authors:Liang Qian, Shao Zheng,Fan Zheng, Wang Weina, Huang Yusen Corresponding author:Huang Yusen, Email:huang_yusen@126.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240612-00150 ABSTRACT Objective To establish a rabbit model of methicillin-resistant Staphylococcus aureus (MRSA) endophthalmitis and to investigate the regulatory effects of the sympatholytic agent guanethidine on the inflammatory response in endophthalmitis. Methods Six male New Zealand white rabbits of about 2.5 kg were selected and […]
Cone and retinal microvasculature distribution characteristics with idiopathic epiretinal membrane
Authors:Wu Jiang, Ye Xin, Zhou Xiangpeng, He Shucheng, Shen Yingjiao, Shen Lijun Corresponding author:Shen Lijun, Email:slj@mail.eye.ac.cn Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20250613-00200 ABSTRACT Objective To investigate cone density and retinal microvascular distribution characteristics in idiopathic epiretinal membrane (IERM) by utilizing multimodal imaging techniques. Methods A self-controlled study was conducted. Twenty-eight patients (56 eyes) with unilateral IERM diagnosed at the Department of […]
Imaging and clinical characteristics of combined central retinal artery and vein occlusion
Authors:Xie Ting, Li Zhi, Cheng Xiaorong, Wang Weiqing, Li Jin, Liang Siying, Li Wangting, Chen Qingshan Corresponding author:Chen Qingshan, Email:cqs1967@sina.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240821-00239 ABSTRACT Objective To analyze the clinical and imaging features of combined central retinal artery and vein occlusion (CCRAVO) and analyze the correlation with visual acuity improvement. Methods An observational case series study was conducted. Fifteen […]
Clinical observation of anti-VEGF therapy for neovascular age-related macular degeneration combined with cataract after surgery
Authors:Wang Qian, Wang Haiyan, Zhang Lei, Ren Yuecong, Yan Hong Corresponding author:Yan Hong, Email:yan2128ts@hotmail.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20250120-00017 ABSTRACT Objective Based on the new classification of macular neovascularization (MNV), to observe the treatment characteristics of anti-vascular endothelial growth factor (VEGF) in patients with neovascular age-related macular degeneration (nAMD) complicated with cataracts after phacoemulsification. Methods A retrospective cohort study was […]
Retinal thickness and optic disc parameters in children with unilateral and bilateral amblyopia
Authors:Zhu Xixi, Zheng Qiaolan, Chen Jie, Chen Wuhe Corresponding author:Chen Wuhe, Email:cwh@eye.ac.cn Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20241126-00323 ABSTRACT Objective To investigate the differences in retinal layer thickness and optic disc parameters in children with unilateral and bilateral amblyopia. Methods A cross-sectional study was conducted. Seventy-nine amblyopic children who were admitted to the Eye Hospital of Wenzhou Medical University from July […]
One-year clinical outcomes of PresbyMAX monocular LASIK for presbyopia correction
Authors:Ma Xiaoqian, Yin Weijing,Ma Ning, Sun Hongyan, Cai Pengpeng, Li Qing, Liu Wenjuan, Liu Subing, Zhou Yuanpei Corresponding author:Zhou Yuanpei, Email: zhouyuanpei850405@163.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20260511-00212 ABSTRACT Objective To evaluate the 1-year efficacy and safety of combining conventional corneal refractive surgery in the dominant eye with PresbyMAX monocular laser in situ keratomileusis (LASIK) in the non-dominant eye for […]
Clinical phenotype and genetic characteristics of a pedigree with autosomal recessive enhanced S-cone syndrome and strabismus caused by pathogenic variants in the NRL gene
Authors:Li Jie, Li Zhanrong, Li Guanfeng, Jiang Yongqiang, Lu Xiaonan, Liu Xiaohui, Dai Shuzhen Corresponding author:Dai Shuzhen, Email: dsz997300056@163.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20251124-00403 ABSTRACT Objective To analyze the clinical phenotypes and genetic characteristics of a Chinese Han pedigree with autosomal recessive enhanced S-cone syndrome (ESCS) caused by pathogenic variants in the Neural retina leucine zipper (NRL) gene, presenting […]
Research progress on the immune mechanism of corneal neovascularization
Authors:Liu Mengxin, Yan Chunxiao,Zhang Lijun Corresponding author: Zhang Lijun, Email: lijunzhangw@sina.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240923-00266 ABSTRACT Corneal neovascularization (CNV) is a common pathological change in many eye diseases, such as infections, inflammation, hypoxia, degeneration, and trauma, which can cause serious visual impairment. Inflammation is the core mechanism of CNV, and various immune cells (macrophages, neutrophils, T cells, and antigen-presenting cells) […]
Oxidative stress-induced mechanisms in corneal neovascularization and targeted therapeutic approaches
Authors:Deng Qian, Wan Shanshan, Yang Yanning Corresponding author: Yang Yanning, Email: yangyanning@whu.edu.cn Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240229-00056 ABSTRACT Corneal neovascularization (CNV) is an ocular surface disorder caused by a variety of diseases, including inflammation, trauma, malnutrition, wearing of corneal contact lenses, etc. Oxidative stress refers to the excessive production of reactive oxygen species or reactive nitrogen species in […]