Authors:Wu Yifei, Wang Yinghui, Jie Ying Corresponding author: Jie Ying, Email:jie_yingcn@aliyun.com Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20260705-00272 ABSTRACT Dry eye is a multifactorial ocular surface disease driven by a combination of factors, including tear film instability, tear hyperosmolarity, ocular surface inflammation, and neurosensory abnormalities. Corneal nerve abnormalities may interfere with reflex tear secretion and corneal epithelial repair, leading to prolonged symptoms and variable […]
Category: Current Issue
Therapeutic effect and mechanism of CELF/HS on bacterial keratitis in mice through inhibiting pyroptosis by downregulating the HK2/NLRP3 and RIPK2/NF-κB signaling pathways
Authors:Wang Mengke, Liu Kang, Wang Wang,Feng Huayang, Li Jiake, Deng Yuting, Li Jingguo, Li Zhanrong Corresponding author: Li Zhanrong, Email:lizhanrong@zzu.edu.cn Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20251007-00330 ABSTRACT Objective To investigate the therapeutic effects of the celastrol-furoxan derivative-loaded nanomicelles (CELF/HS) on Staphylococcus aureus (SA)-induced bacterial keratitis in mice and its effects on the hexokinase 2 (HK2)/NOD-like receptor protein 3 (NLRP3) and receptor-interacting protein kinase 2 (RIPK2)/nuclear factor-κB (NF-κB) signaling pathways and […]
Comparison of the clinical efficacy of liquid pulsation technology combined with cyclosporine A and meibomian gland expression combined with cyclosporine A for moderate meibomian gland dysfunction
Authors:Zhu Lei, Hao Yiran, Zhao Mengnan, Tian Lei, Jie Ying Corresponding author: Jie Ying, Email:jie_yingcn@aliyun.com Published:2026-10-10 DOI: 10.3760/cma.j.cn115989-20260103-00002 ABSTRACT Objective To evaluate the clinical efficacy of a domestic liquid pulsation technology (LPT) dry eye treatment device combined with cyclosporine A eye drops in treating moderate meibomian gland dysfunction (MGD), and to compare it with conventional meibomian gland expression. Methods A randomized controlled […]
Comparison of efficacy between platelet-rich plasma and 20% autologous serum in treating refractory corneal epithelial defects
Authors:Zhou Yanrong, Zhao Wenxin, Zhang Ming, Dang Yufei, Li Li Corresponding author: Li Li, Email:eyelili@126.com Published:2026-10-10 DOI: 10.3760/cma.j.cn115989-20260310-00111 ABSTRACT Objective To compare the efficacy of platelet-rich plasma (PRP) versus 20% autologous serum (AS) in treating refractory corneal epithelial defects (RCED). Methods A cohort study was conducted. A total of 50 consecutive patients (50 eyes) with RCED who were treated at the First […]
Correlation and predictive value of IL-6, TGF-β, and IL-17 with corneal graft rejection
Authors:Zhang Yongqian, He Lifen, Wang Jiusan, Xie Yongxian, Cao Qian, Li Lan Corresponding author: Li Lan, Email:641106144@qq.com Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20260306-00095 ABSTRACT Objective To investigate the correlation and predictive value of interleukin (IL)-6, transforming growth factor-β (TGF-β), and IL-17 expression levels in peripheral blood and tears with corneal graft rejection after penetrating keratoplasty (PKP). Methods A cross-sectional study was conducted. A total of 78 […]
Superiority of lacrimal gland long axis in lacrimal gland size evaluation: a high-resolution MRI study in Chinese adults
Authors:Zhou Tianyu, Huang Xiaoyu, Shen Jiachao, Zhong Hongtao, Li Guigang Corresponding author: Li Guigang, Email:guigangli@hust.edu.cn Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20260310-00109 ABSTRACT Objective To establish reference data for lacrimal gland size in Chinese adults using high-resolution magnetic resonance imaging (MRI), and to investigate the correlations between lacrimal gland size and demographic parameters (sex, age, height, weight, and body mass index [BMI]). Methods A cross-sectional study […]
Efficacy of perioperative 0.05% cyclosporine A for dry eye in cataract patients: a randomized controlled clinical trial
Authors:Zhumahan Tuokedaerhan, Wang Yan, Li Xiaolong, Cheng Wanying, Gao Yunxian Corresponding author: Gao Yunxian, Email:gaoyx1973@163.com Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20250602-00179 ABSTRACT Objective To evaluate the efficacy of 0.05% cyclosporine A eye drops for the perioperative treatment of dry eye in patients to undergo cataract surgery. Methods A randomized controlled study was conducted. Sixty patients (60 eyes) with cataract and mild-to-moderate dry eye disease treated […]
Health management for patients with ametropia and dry eye disease
Authors:Zhang Yongyi, He Hui, Qu Lijun Corresponding author: Qu Lijun, Email:qulijun@hrbmu.edu.cn Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20260309-00104 ABSTRACT Ametropia and dry eye disease are two common ocular conditions that can occur in people of all ages and are often closely linked through complex pathophysiology. Patients with ametropia may have corneal shape abnormalities and eyelid dysfunction, which could be associated with dry eye disease […]
Advances in morphological assessment methods for tear meniscus
Authors:Liu Wenqi, Feng Jun, Jie Ying Corresponding author: Jie Ying, Email:jie_yingcn@aliyun.com Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20241129-00328 ABSTRACT Accurate assessment of tear meniscus morphology is critical for the diagnosis and treatment of ocular surface diseases such as dry eye disease. It has been found that the measurement of tear meniscus parameters is affected by a variety of factors and has become more accurate […]
Research progress on meibomian gland stem/progenitor cells
Authors:Wang Gongyue,Zhang Yijia,Zhang Mingchang,Xie Huatao Corresponding author: Xie Huatao, Email:huataoxie@hust.edu.cn Published:2026-10-10 DOI:10.3760/cma.j.cn115989-20260309-00098 ABSTRACT Meibomian gland dysfunction is recognized as the primary cause of dry eye. As a lipid-secreting gland, the normal renewal and secretory function are essential for maintaining tear film stability and ocular surface homeostasis. Findings from lineage tracing, single-cell transcriptomics, and organoid models suggest that several spatially distinct […]