Authors:Wang Junwen, Ma Yunxi, Sun Xufang Corresponding author: Sun Xufang, Email: sunxufang2016@163.com Published:2026-09-10 DOI: Neovascular age-related macular degeneration (nAMD) is one of the leading causes of central vision loss and irreversible blindness in the elderly population. Its core pathological features include choroidal neovascularization, exudation, hemorrhage, and scarring. In recent years, although anti-vascular endothelial growth factor (anti-VEGF) therapy has significantly […]
Category: Current Issue
Inhibitory effect of engineered exosomes loaded with A485 on hypoxia-induced pathological neovascularization by targeted inhibition of lactylation
Authors:Fan Yuanyuan,Luo Yufan, Xie Ping, Hu Zizhong Corresponding author: Hu Zizhong, Email: huzizhong@njmu.edu.cn Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260427-00191 ABSTRACT Objective To construct engineered exosomes loaded with the p300 inhibitor A485 (A485@EV) and to investigate their effects and mechanisms in inhibiting hypoxia-induced pathological neovascularization by targeting inhibition of lactylation. Methods A485@EV was prepared by sonication, and its markers, morphology and physical and chemical properties […]
Ameliorative effect of acteoside on high glucose-induced oxidative stress and mitochondrial damage by modulating SIRT1-mediated mitophagy in RPE cells
Authors: Shen Shuhong, Li Yan, Ma Jia, Chen Qianbo, Xi Xiaoting Corresponding author: Xi Xiaoting, Email:xi_xiao_ting@163.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260330-00144 ABSTRACT Objective To investigate the regulatory effect and molecular mechanism of acteoside on oxidative stress and mitochondrial damage in high glucose-induced human retinal pigment epithelial cells (ARPE-19). Methods ARPE-19 cells were divided into normal control group, mannitol group, high-glucose group, high-glucose+Mito-TEMPO (reactive oxygen […]
Changes in neutrophil-to-lymphocyte ratio in different subtypes of diabetic retinopathy
Authors:Wang Manqiao, Liu Boshi, Li Xiaorong Corresponding author: Li Xiaorong, Email: xiaorli@163.com Published:2026-09-10 DOI: 10.3760/cma.j.cn115989-20260331-00149 ABSTRACT Objective To investigate the changes in the neutrophil-to-lymphocyte ratio (NLR) in different subtypes of diabetic retinopathy (DR). Methods A case-control study was conducted. From September 2023 to May 2024, 174 patients with DR and 57 patients with simple age-related cataract were enrolled at […]
A real-world study on related factors of diabetic retinopathy in patients with type 2 diabetes mellitus
Authors:Yang Yingrui, Xu Xun, Sun Jiali, Chen Yanyan, Zhang Mengyue, Huang Zixu, Fan Shuoning, Song Zongming Corresponding authors: Fan Shuoning, Email: fanshuoning@126.com; Song Zongming, Email: szmeyes@126.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20251230-00459 ABSTRACT Objective To explore the correlative factors for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM), so as to provide evidence for identifying high-risk populations in clinical practice. Methods A single-center, retrospective cross-sectional real-world […]
Association between TyG index and the risk of DR and the effect modification of abdominal obesity: a cohort study based on the UK Biobank
Authors: Chen Xi, Yuan Mingzhu, Xie Jinchi, Tan Yuhe, Yang Runze, Geng Tingting, Sun Xufang Corresponding author: , Email: sunxufang2016@163.com Published:2026-09-10 DOI: 10.3760/cma.j.cn115989-20260424-00188 ABSTRACT Objective To investigate the association between the triglyceride-glucose (TyG) index and the risk of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM), and the effect modification of abdominal obesity. Methods Based on data from the […]
Dual role of microglia and macrophages in the oxygen-induced retinopathy model: pathogenic mechanisms and therapeutic potential
Authors:Liu Wenhui, Gao Jingzhao, Su Lin, Li Xiaorong Corresponding author: Li Xiaorong , Email: xiaorli@163.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260331-00151 ABSTRACT Oxygen-induced retinopathy (OIR) is an important animal model for retinal neovascular diseases. In recent years, increasing evidence has shown that alterations in the retinal immune microenvironment are involved throughout the development and progression of OIR, among which myeloid immune cells, such as […]
Research progress on neuroimmune interactions in diabetic retinopathy
Authors:Zhang Danlei, Hou Shengping Corresponding author: Hou Shengping, Email: sphou828@163.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260422-00186 ABSTRACT Diabetic retinopathy (DR) is a common microvascular complication of diabetes and one of the main blinding eye diseases. Recent studies have shown that retinal neurodegenerative changes and chronic low-grade inflammation can occur in the early stage of DR and participate in the progression of the […]
Choroidal neovascularization: multipathway pathological mechanisms and novel synergistic therapeutic strategies
Authors:Yao Mudi, Liu Qian, Yan Biao Corresponding author: Yan Biao, Email: yanbiao@sjtu.edu.cn Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20251215-00428 ABSTRACT Choroidal neovascularization (CNV) represents a common blinding terminal pathological change across various fundus diseases. Although anti-vascular endothelial growth factor (VEGF) therapy has become the standard of care, long-term clinical practice has revealed significant limitations, including drug resistance, the burden of frequent injections, and the […]
Advances in the application of adaptive optics retinal imaging in diabetic retinopathy
Authors:Wang Xufan, Bai Wen, Yao Jin Corresponding author: Yao Jin, Email: dryaojin@126.com Published:2026-09-10 DOI:10.3760/cma.j.cn115989-20260407-00164 ABSTRACT Diabetic retinopathy (DR) is a common microvascular complication in patients with diabetes. It is also an important cause of visual impairment in working-age adults. Color fundus photography, fundus fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography are commonly used for DR screening, […]