Authors: Zhao Wenxin, Zhang Xian, Qin Yazhou, Zhang Ming, Gao Ning, Qin Li, Li Jingming DOI: 10.3760/cma.j.cn115989-20200320-00188 Published 2024-07-10 Cite as Chin J Exp Ophthalmol, 2024, 42(7): 602-612. Abstract 【Download PDF】【Read Full Text】 Objective To investigate the pathogenic role and possible mechanism of […]
Tag: Disease model
Construction and research progress of organoid models for retinitis pigmentosa
Authors: Xie Linyao, Chen Jiansu, Guo Yonglong DOI: 10.3760/cma.j.cn115989-20230808-00061 Published 2024-05-10 Cite as Chin J Exp Ophthalmol, 2024, 42(5): 473-477. Abstract [Download PDF] [Read Full Text] After more than ten years of development, retinal organoid (RO) based on pluripotent stem cells can […]
Modulation of MEK/ERK and PI3K/Akt pathways to the expression of DDR2 and MMP-13 in choroidal neovascularization
Authors: Yang Xiumei, Wang Yusheng, Zhang Jian, Li Yan, Yao Libo DOI: 10.3760/cma.j.issn.2095-0160.2015.08.002 Published 2015-08-10 Cite as Chin J Exp Ophthalmol, 2015,33(8): 678-685. Abstract [Download PDF] [Read Full Text] Background It is estimated that discoidin domain receptor 2 (DDR2) and matrix metalloproteinase-13 […]
In vitro-expansion of induced regulatory T cells and its inhibitory effects on corneal allograft rejection
Authors: Wei Tongxin, Li Guangling, Guo Xuming DOI: 10.3760/cma.j.issn.2095-0160.2015.10.007 Published 2015-10-10 Cite as Chin J Exp Ophthalmol, 2015,33(10): 896-901. Abstract [Download PDF] [Read Full Text] Background Researches showed that CD4+ CD25+ natural regulatory T cells (nTregs) play an important role in maintaining peripheral immune […]
Inhibitory effect of radixin shRNA on retinal neovascularization induced by hyperoxia in mice
Authors: Wang Longmei, Yang Xia, Yan Lin, Liu Ting, Dong Xiaoguang, Xu Haifeng DOI: 10.3760/cma.j.issn.2095-0160.2015.12.008 Published 2015-12-10 Cite as Chin J Exp Ophthalmol, 2015,33(12): 1089-1094. Abstract [Download PDF] [Read Full Text] Background Retinal neovascularization is pathological basis of a variety of fundus […]
Dynamic expression of intercellular adhesion molecule-1 in laser-induced choroidal neovascularization in Brown Norway rats
Authors: Gao Xiaoyan, He Shouzhi DOI: 10.3760/cma.j.issn.2095-0160.2015.12.011 Published 2015-12-10 Cite as Chin J Exp Ophthalmol, 2015,33(12): 1103-1107. Abstract [Download PDF] [Read Full Text] Background Extracellular matrix (ECM) has various kinds of types and important biological function.The important role of ECM during choroidal […]
Changes in DNA methylation of retinal gene promoter regions and their significance in type 1 diabetic rats
Authors: Li Yahong, Geng Chao, Liu Shengnan, Wang Qi, Li Xiaorong, Zhang Yan DOI: 10.3760/cma.j.cn115985-20190616-00262 Published 2020-04-10 Cite as Chin J Exp Ophthalmol, 2020,38(04): 291-299. Abstract [View PDF] [Read Full Text] Objective To study the methylation level of retinal gene promoter region […]
Protective effects of folic acid on retina in diabetic mice and its anti-oxidative stress mechanism
Authors: Li Yinglan, Wu Min, Xue Xiaoqin, Li Changxing, Lei Youfang, Dai Dongfang DOI: 10.3760/cma.j.issn.2095-0160.2020.01.005 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 23-30. Abstract [View PDF] [Read Full Text] Objective To explore the protective effects of folic acid on retinas and its anti-oxidative stress […]
Research progress of Cre/LoxP system in the eyes of animal model
Authors:Lou Xiangfeng, Luo Xue, Shen Yin DOI: 10.3760/cma.j.issn.2095-0160.2019.09.015 Published 2019-09-10 Cite as Chin J Exp Ophthalmol, 2019,37(9): 759-763. Abstract [View PDF] [Read Full Text] Cre/LoxP system has been widely used as new type of gene targeting, which can transform genes in specific tissues and organs, remove specific […]
Suppressing effect of p21WAF1/CIP1 on traumatic proliferative vitreoretinopathy in rabbits
Authors: Yuan Zhigang, You Caiyun, Han Jindong, Li Haiyan, Yan Hua DOI: 10.3760/cma.j.issn.2095-0160.2016.05.008 Published 2016-05-10 Cite as Chin J Exp Ophthalmol, 2016,34(5): 420-425. Abstract [Download PDF] [Read Full Text] Background p21 is a cyclin-dependent kinase inhibitor, and it can prevent cells from going through the G1/S […]