Category: Experimental Science

Inhibition of roscovitine on the activity of Cdk5/p25 and phosphorylation of tau in retina of RCS rats after intravitreal injection

Authors: Zhang Jinjin,  Sheng Xunlun,  Ren Yinghua,  Rong Weining,  Li Huiping,  Liu Yani DOI: 10.3760/cma.j.issn.2095-0160.2015.01.002 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 5-9. Abstract                              [Download PDF] [Read Full Text] Background Study determined that retinitis pigmentosa has a similar pathogenesis mechanism […]

Regulation of microRNA to the expression of matrix metalloproteinases in bone marrow-derived cells in mice with choroidal neovascularization

Authors: Lyu Yang,  Hou Huiyuan,  Wang Yusheng DOI: 10.3760/cma.j.issn.2095-0160.2015.01.003 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 10-15. Abstract                              [Download PDF] [Read Full Text] Background Matrix metalloproteinases (MMPs) play important roles in the formation of choroidal neovascularization (CNV), but its mail […]

Mitochondrial pathway of retinal pigment epithelial cell apoptosis induced by blue light in vitro

Authors: Li Hong,  Lyu Jianping,  Cai Shanjun,  Su Gang,  Wu Zhipeng,  Gong Xin DOI: 10.3760/cma.j.issn.2095-0160.2015.01.004 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 16-20. Abstract                              [Download PDF] [Read Full Text] Background Studies determined that blue light exposure causes apoptosis of human […]

Epithelial-mesenchymal transition of human retinal pigment epithelial cells under the high glucose condition in vitro

Authors: Hou Dingshan,  Li Ruishu,  Fan Yan,  Bi Wenjiao,  Zhang Xiaomei DOI: 10.3760/cma.j.issn.2095-0160.2015.01.005 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 21-26. Abstract                              [Download PDF] [Read Full Text] Background Several types of cells participate in the formation of proliferative membrane in […]

Inhibitory effect of ursolic acid on high oxygen-induced mouse retinal neovascularization by intravitreal injection

Authors: He Ling,  Zheng Xiaolong,  Zhang Jie,  Zhang Shanfeng,  Yu Xiaohong,  Tian Fang DOI: 10.3760/cma.j.issn.2095-0160.2015.01.006 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 27-32. Abstract                             [Download PDF] [Read Full Text] Background Retinal neovascular diseases affect visual function.Although many drugs have been used […]

Promoting proliferation and inhibiting apoptosis effects of sphingosine-1-phospate on human retinal pigment epithelium cells under the hypoxic condition

Authors: Fan Yan,  Lu Hong,  Hou Dingshan,  Bi Wenjiao,  Zhang Xiaomei DOI: 10.3760/cma.j.issn.2095-0160.2015.01.007 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 33-37. Abstract                            [Download PDF] [Read Full Text] Background Sphingosine-1-phospate (S1P) is a bioactive lipid and important messenger molecule in cells.It participates […]

Effect of urokinase on the outward permeability of blood-retinal barrier following local injection in rats

Authors: Xu Wenjun,  Gao Yongfeng,  Hu Ping DOI: 10.3760/cma.j.issn.2095-0160.2015.01.008 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 38-41. Abstract                              [Download PDF] [Read Full Text] Background Retinal vascular recanalization is key to the treatment of retinal vascular occlusive disease.Studies confirmed that urokinase […]

Expressions of VEGFR-1 and VEGFR-2 in mouse retinas with oxygen-induced retinopathy

Authors: Zhu Dan,  Xin Jifu,  Guo Kai DOI: 10.3760/cma.j.issn.2095-0160.2015.01.009 Published 2015-01-10 Cite as Chin J Exp Ophthalmol, 2015,33(1): 42-46. Abstract                              [Download PDF] [Read Full Text] Background Retinopathy of prematurity (ROP) causes blindness due to retinal vasculopathy caused by abnormal oxygen dynamics.Studies […]

Optimization of reference genes for microRNA expression analysis in a mouse model of oxygen-induced retinopathy

Authors: Bo Qiyu,  Zhou Yu,  Li Xiaorong,  Zhang Yan,  Wang Fei DOI: 10.3760/cma.j.issn.2095-0160.2015.02.002 Published 2015-02-10 Cite as Chin J Exp Ophthalmol, 2015,33(2): 102-108. Abstract                              [Download PDF] [Read Full Text] Background Retinal neovascularization varies with the change of microRNA (miRNA) expression level.Quantitative real-time […]

Defect of Nrf2-ARE signaling activation in corneal stromal cells of keratoconus

Authors: Bian Jiang,  Qu Mingli,  Wang Yao,  Yang Lingling,  Shi Weiyun,  Zhou Qingjun DOI: 10.3760/cma.j.issn.2095-0160.2015.02.003 Published 2015-02-10 Cite as Chin J Exp Ophthalmol, 2015,33(2): 109-114. Abstract                              [Download PDF] [Read Full Text] Background Recent researches show that oxidative stress is involved in the […]