Authors: Chen Jia, Yang Ying, Su Shu, Zhang Shenglai, Yang Xiaowei, Sang Aimin DOI: 10.3760/cma.j.cn115989-20240207-00042 Published: 2025 -10 -10 Citation Chen Jia, Yang Ying, Su Shu, et al. Promotive effect of hypoxia-induced ANGPTL4 expression on experimental choroidal neovascularization[J]. Chin J Exp Ophthalmol, 2025, 43(10):906-914. DOI: 10.3760/cma.j.cn115989-20240207-00042. ABSTRACT […]
Tag: Small interfering RNA
Effect of interfering hsa_circ_0103232 on the biological behavior of uveal melanoma cells
Authors: Yang Xuan, Wei Wenbin DOI: 10.3760/cma.j.cn115989-20231122-00179 Published 2024-03-10 Cite as Chin J Exp Ophthalmol, 2024, 42(3): 224-231. Abstract [Download PDF] [Read Full Text] Objective To investigate the effects of interference with hsa_circ_0103232 on the proliferation, metastasis, cell cycle and apoptosis of […]
Construction and assessment of recombinant plasmid pRNAT-U6.1/CFB siRNA and its inhibitory effect on proliferation of human umbilical vein endothelial cells
Authors: Tong Huan, Shang Qingli, Ma Jingxue, Gao Jian, Wang Xin DOI: 10.3760/cma.j.issn.2095-0160.2015.08.003 Published 2015-08-10 Cite as Chin J Exp Ophthalmol, 2015,33(8): 686-690. Abstract [Download PDF] [Read Full Text] Background Choroidal neovascularization (CNV) is one of the causes of blindness in multiple […]
Inhibitory effect of siRNA-Pax6 on biological behavior and epithelial-mesenchymal transition of human lens epithelial cells
Authors: Zheng Yuxing, Yang Xiaoxi, Yi Guoguo, Wu Shuduan, Feng Zhizhen, Xia Zhaoxia DOI: 10.3760/cma.j.cn115989-20210423-00272 Published 2022-06-10 Cite asChin J Exp Ophthalmol, 2022, 40(6): 499-506. Abstract [View PDF] [Read Full Text] Objective To explore the effect of […]
Inhibitory effect of ILK-siRNA-AAV on scar formation after glaucoma filtering surgery in rats
Authors: Xing Yao, Wang Jianming, Fan Yazhi, Xiong Lei, Wang Wenjing, Cui Lijun DOI: 10.3760/cma.j.cn115989-20210617-00362 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 316-325. Abstract [View PDF] [Read Full Text] Objective To investigate the role of integrin-linked kinase (ILK)-small interfering RNA (siRNA)-adeno-associated virus (AAV) […]
Inhibitory effect of siRNA-YAP1 on transforming growth factor β2-induced epithelial-mesenchymal transition in human lens epithelial cells
Authors: Zheng Liu, Hu Chao, Yang Binbin, Yang Xinggang, Ding Zhixiang DOI: 10.3760/cma.j.cn115989-20191016-00447 Published 2021-04-10 Cite asChin J Exp Ophthalmol, 2021, 39(4): 289-296. Abstract [View PDF] [Read Full Text] Objective To investigate the inhibitory effect of small interfering RNA-Yes-associated protein 1 (siRNA-YAP1) on epithelial-mesenchymal transition […]
Inhibitory effect of small interfering RNA-TLR9 on high glucose-induced retinal ganglion cell apoptosis
Authors: Yang Huihui, Kan Quane, Yu Lu, Li Xuqing, Huang Aiguo, Yuan Huijuan DOI: 10.3760/cma.j.issn.2095-0160.2019.10.008 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 38-44. Abstract [View PDF] [Read Full Text] Objective To investigate the effect of Toll-like receptor 9 (TLR9) on high glucose-induced retinal ganglion […]
The efficiency and safety assessment of Entranster™ nanoparticle carrier for CD25 siRNA transfection in rat cornea
Authors：Qin Qin, Shi Yunjie, Zhao Min DOI: 10.3760/cma.j.issn.2095-0160.2016.10.005 Published 2016-10-10 Cite as Chin J Exp Ophthalmol, 2016,34(10): 888-895. Abstract [Download PDF] [Read Full Text] Background Gene transfection is an effective therapeutic avenue to target many kinds of eye diseases.Non-viral vectors with high transfection efficiency, long-term expression, […]
The proliferative inhibition and apoptosis promotion of Smac on human lens epithelial cells
Authors: Kong Deqian, Zheng Guangying, Li Li, Liu Yue, Cai Fangfei DOI: 10.3760/cma.j.issn.2095-0160.2017.03.010 Published 2017-03-10 Cite as Chin J Exp Ophthalmol, 2017,35(3): 233-238. Abstract [Download PDF] [Read Full Text] Background Posterior capsular opacification (PCO) is a primary complication after extracapsular cataract extraction.The mechanism of PCO is associated with proliferation, migration and […]
The promoting effects of SNAI1 activating matrix metalloproteinase on choroidal neovascularization under hypoxia
Authors: Sun Jiaxing, Dou Guorui, Chang Tianfang, Li Manhong, Yang Ziyan, Yan Xianchun, Liu Yuan, Han Hua, Wang Yusheng DOI: 10.3760/cma.j.issn.2095-0160.2018.01.004 Published 2018-01-10 Cite as Chin J Exp Ophthalmol, 2018,36(1): 16-22. Abstract [Download PDF] [Read Full Text] Objective To investigate whether vascular endothelial cells in choroidal neovascularization whether hypoxia condition can up-regulate SNAI1 and […]