Authors:Liu Mengxin, Yan Chunxiao,Zhang Lijun Corresponding author: Zhang Lijun, Email: lijunzhangw@sina.com Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240923-00266 ABSTRACT Corneal neovascularization (CNV) is a common pathological change in many eye diseases, such as infections, inflammation, hypoxia, degeneration, and trauma, which can cause serious visual impairment. Inflammation is the core mechanism of CNV, and various immune cells (macrophages, neutrophils, T cells, and antigen-presenting cells) […]
Tag: Corneal neovascularization
Oxidative stress-induced mechanisms in corneal neovascularization and targeted therapeutic approaches
Authors:Deng Qian, Wan Shanshan, Yang Yanning Corresponding author: Yang Yanning, Email: yangyanning@whu.edu.cn Published:2026-07-10 DOI:10.3760/cma.j.cn115989-20240229-00056 ABSTRACT Corneal neovascularization (CNV) is an ocular surface disorder caused by a variety of diseases, including inflammation, trauma, malnutrition, wearing of corneal contact lenses, etc. Oxidative stress refers to the excessive production of reactive oxygen species or reactive nitrogen species in […]
Progress in the treatment of corneal neovascularization with anti-VEGF drugs
Authors: Li Shiding, Chen Liangbo, Fu Yao Published: 2026 -06 -10 DOI: 10.3760/cma.j.cn115989-20230601-00206 Citation Li Shiding, Chen Liangbo, Fu Yao. Progress in the treatment of corneal neovascularization with anti-VEGF drugs[J]. Chin J Exp Ophthalmol, 2026, 44(6):584-589. DOI: 10.3760/cma.j.cn115989-20230601-00206. ABSTRACT [Download PDF] [Read Full Text] The cornea is an important refractive […]
Role and mechanism of PRMT1 and its inhibitors in the occurrence and development of corneal neovascularization in mice
Authors: Gao Yuelan, Deng Qian, Mao Jiewen, Zhang Rui, Shi Xiaoshuo, Wan Shanshan, Yang Yanning DOI: 10.3760/cma.j.cn115989-20240311-00070 Published: 2025 -08 -10 Citation Gao Yuelan, Deng Qian, Mao Jiewen, et al. Role and mechanism of PRMT1 and its inhibitors in the occurrence and development of corneal neovascularization in mice[J]. Chin J Exp Ophthalmol, 2025, 43(8):688-703. DOI: 10.3760/cma.j.cn115989-20240311-00070. ABSTRACT […]
Inhibitory effect of exosome-loaded KV11 on corneal neovascularization via VDAC1 and autophagy
Authors: Chen Wenqian, Du Wei, Yu Wenzhen DOI: 10.3760/cma.j.cn115989-20220402-00132 Published 2024-02-10 Cite as Chin J Exp Ophthalmol, 2024, 42(2): 108-116. Abstract 【Read Full Text】【Download PDF】 Objective To investigate the effects and mechanism of exosome (EXO)-loaded kringle V11 (KV11) delivery on corneal neovascularization (CNV). Methods […]
Inhibitory effect of miR-497 on corneal neovascularization and its regulation mechanism targeting STAT3
Authors: Wang Yang, Yang Yanning, Pan Yumiao, Huang Yuqing, Zhou Yiwen DOI: 10.3760/cma.j.cn115989-20210201-00084 Published 2023-03-10 Cite as Chin J Exp Ophthalmol, 2023, 41(3): 206-216. Abstract [Download PDF] [Read Full Text] Objective To investigate the role of microRNA (miR)-497 in the formation of […]
Advances in anti-VEGF/VEGFR targeting drugs for corneal neovascularization
Authors: Wang Qun, Huang Yifei DOI: 10.3760/cma.j.issn.2095-0160.2015.12.018 Published 2015-12-10 Cite as Chin J Exp Ophthalmol, 2015,33(12): 1138-1143. Abstract [Download PDF] [Read Full Text] Cornea is an important part of the refractive media.Healthy cornea is clear and avascular.Corneal avascularity is necessary for the […]
Inhibitory effect of vorinostat encapsulated hydroxypropyl-β-cyclodextrin eye drops on corneal neovascularization induced by alkali burns in mouse
Authors: Yang Jingjing, Liang Zhen, Lu Ping, Zhang Zhen, Zhang Junjie DOI: 10.3760/cma.j.cn115989-20200807-00566 Published 2022-07-10 Cite asChin J Exp Ophthalmol, 2022, 40(7): 609-616. Abstract [View PDF] [Read Full Text] Objective To prepare vorinostat encapsulated hydroxypropyl-β-cyclodextrin (SAHA-CD) eye drops and investigate its inhibitory […]
Progress in matrix metalloproteinase 2 and 9 regulating corneal neovascularization
Authors: Zhang Jiahao, Zhang Yan, He Yuxi DOI: 10.3760/cma.j.cn115989-20190226-00085 Published 2020-10-10 Cite as Chin J Exp Ophthalmol, 2020,38(10): 900-904. Abstract [View PDF] [Read Full Text] Corneal neovascularization (CNV) is a pathological process of angiogenesis that can cause severe corneal damage.CNV has been widely demonstrated to […]
Inhibiting effect of subconjuctivally injected conbercept on experimental corneal neovascularization and lymphangiogenesis in rabbit
Authors: Chen Xiaoxia, Li Jing, Gu Zhencheng DOI: 10.3760/cma.j.cn115989-20190327-00149 Published 2020-07-10 Cite as Chin J Exp Ophthalmol, 2020,38(07): 581-588. Abstract [View PDF] [Read Full Text] Objective To investigate the value of conbercept in experimental corneal nevascularization (CNV) and lymphangiogenesis in rabbit model. Methods Forty-four adult New […]