Authors：Yin Jie, Wang Yusheng DOI: 10.3760/cma.j.issn.2095-0160.2016.12.018 Published 2016-12-10 Cite as Chin J Exp Ophthalmol, 2016,34(12): 1132-1135. Abstract [Download PDF] [Read Full Text] Being regarded as one kind of specialized tissue macrophages in central nervous system, microglia plays a key role in maintenance of retinal integrity and function.However, recent investigations have […]
Tag: Neovascularization
Relationship of human microvascular endothelial cell activation and adenosine level under the hypoxia
Authors: Ai Liqianyu, Huang Chanjuan, Chen Chen, Lin Sen, Ye Jian DOI: 10.3760/cma.j.issn.2095-0160.2017.01.006 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 26-31. Abstract [Download PDF] [Read Full Text] Background Retinal hypoxia is one of primary causes of retinal neovascularization, and its mechanism is research hot topic.Studies showed that hypoxia […]
Role of cysteine-rich protein 61 in ocular neovascular disease
Authors: Guo Jiaxian, Sun Xiaodong DOI: 10.3760/cma.j.issn.2095-0160.2017.02.020 Published 2017-02-10 Cite as Chin J Exp Ophthalmol, 2017,35(2): 189-192. Abstract [Download PDF] [Read Full Text] Cysteine-rich protein 61 (CYR61) is a secreted protein.It consists of four different structural domains and plays an important role in all kinds of cell […]
Recent advances of micro RNA in neovascularization formation of diabetic retinopathy
Authors: Huang Jun, Mao Xinbang DOI: 10.3760/cma.j.issn.2095-0160.2017.05.020 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 478-480. Abstract [Download PDF] [Read Full Text] MicroRNA (miRNA) is a kind of endogenous and highly conservative RNA, with length of about 20 to 24 nucleotides and tissue specificity.MiRNA regulates the […]
Inhibitory effects of microRNA-375 on biological behaviour of human retinal capillary endothelial cells induced by hypoxia
Authors: Zhu Jiang, Ren Mei, Xu Zhiguo DOI: 10.3760/cma.j.issn.2095-0160.2017.08.005 Published 2017-08-10 Cite as Chin J Exp Ophthalmol, 2017,35(8): 695-702. Abstract [Download PDF] [Read Full Text] Background Studies showed that microRNA (miR)-375 suppresses the growth, apoptosis, migration and adhesion of tumor cells, and it plays a regulation to the […]
Effect of DNA damage marker γH2AX in the process of oxygen-induced retinal neovascularization
Authors: Li Ruolin, Chen Nan, Meng Lili, Zhu Hong DOI: 10.3760/cma.j.issn.2095-0160.2017.10.005 Published 2017-10-10 Cite as Chin J Exp Ophthalmol, 2017,35(10): 879-884. Abstract [Download PDF] [Read Full Text] Background Changes in the concentration of oxygen induced retinal neovascularization and DNA damage repair response.Overexpression of angiogenic factors is […]
The effects of recombinant human platelet derived growth factor-BB on biological behaviours of human retinal vascular endothelial cells
Authors: Li Dan, Liu Gaoqin, Chen Lei, Wang Mengjiao, Lu Peirong DOI: 10.3760/cma.j.issn.2095-0160.2018.01.008 Published 2018-01-10 Cite as Chin J Exp Ophthalmol, 2018,36(1): 34-39. Abstract [Download PDF] [Read Full Text] Objective This study was to investigate the role of recombinant human platelet derived growth factor-BB(rhPDGF-BB) in the proliferation and migration of […]
Inhibitory effects of Genistein on hyperoxia-induced retinal neovascularization
Authors: He Ronghua, Zhou Guohong, Kong Li, Li Chenyu DOI: 10.3760/cma.j.issn.2095-0160.2018.01.007 Published 2018-01-10 Cite as Chin J Exp Ophthalmol, 2018,36(1): 29-33. Abstract [Download PDF] [Read Full Text] Objective To investigate the effect of Genistein, a tyrosinase inhibitor, on retinal neovascularization in mice. Methods Thirty-six 7-day-old C57BL/6J mice were randomly […]
Problems and challenges of anti-vascular endothelial growth factor therapy for ocular neovescularization diseases
Authors: Chen Youxin, Tang Jia DOI: 10.3760/cma.j.issn.2095-0160.2019.01.001 Published 2019-01-10 Cite as Chin J Exp Ophthalmol, 2019,37(1): 1-4. Abstract [Download PDF] [Read Full Text] Anti-vascular endothelial growth factor (VEGF) therapy is a major strategy for treating ocular neovascular diseases nowadays.It has revolutionarily improved the […]