Authors: Yang Ming, Wang Zhiju, Deng Tingting, Pan Lin DOI: 10.3760/cma.j.issn.2095-0160.2017.03.007 Published 2017-03-10 Cite as Chin J Exp Ophthalmol, 2017,35(3): 217-224. Abstract [Download PDF] [Read Full Text] Background The pathogenesis mechanism of diabetic cataract has not been fully elucidated.Researches showed that multiple biological pathways participate in the pathogenesis of […]
Tag: Oxidative stress
Excitatory toxicity of glutamate on meningothelial cells of optic nerve sheaths and its oxidative stress mechanism
Authors: Xin Xiaorong, Gong Tianxiang, Hong Ying, Dang Hong DOI: 10.3760/cma.j.issn.2095-0160.2017.05.009 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 432-437. Abstract [Download PDF] [Read Full Text] Background Meningothelial cells (MECs) occupy the predominant cell component of barrier between optic nerve and the cerebral spinal fluid, and any change […]
Mediated effects of endoplasmic reticulum stress on light-induced apoptosis and inflammation of human retinal pigment epithelial cell
Authors: Jiang Wenjing, Zhang Lina, Yu Xiao, Niu Yingjun DOI: 10.3760/cma.j.issn.2095-0160.2017.09.010 Published 2017-09-10 Cite as Chin J Exp Ophthalmol, 2017,35(9): 816-823. Abstract [Download PDF] [Read Full Text] Background The light damage model of retinal pigment epithelium (RPE) cells is a research direction of retinal degeneration diseases, and RPE cell […]
Neuroprotective effects of brimonidine on retinal ganglion cells induced by oxidative stress mitochondrial dysfunction
Authors: Wang Lu, Lin Binwu, Wang Yan, Pang Long DOI: 10.3760/cma.j.issn.2095-0160.2018.01.003 Published 2018-01-10 Cite as Chin J Exp Ophthalmol, 2018,36(1): 12-15. Abstract [Download PDF] [Read Full Text] Objective To explore whether brimonidine has a protective effect on retinal ganglion cells (RGCs) through improving mitochondrial function under the oxidative stress. […]
Role of mitochondrial DNA in human retinal pigment epithelium cells apoptosis induced by blue light
Authors: Zhou Wenjie, Yu Yongzhen, Xu Zhe, Zou Xiulan, Li Dandan, Zou Yuping DOI: 10.3760/cma.j.issn.2095-0160.2018.04.008 Published 2018-04-10 Cite as Chin J Exp Ophthalmol, 2018,36(4): 267-272. Abstract [Download PDF] [Read Full Text] Objective To research the role of mitochondrial DNA mediate the cultured human retinal pigment epithelium (hRPE) cell apoptosis induced by […]
Research progress of the relationship between Sirtuins and diabetic retinopathy
Authors: Gao Jian, Xu Yajing, Liu Lun DOI: 10.3760/cma.j.issn.2095-0160.2018.09.016 Published 2018-09-10 Cite as Chin J Exp Ophthalmol, 2018,36(9): 733-736. Abstract [Download PDF] [Read Full Text] As one of the serious complications of diabetes melitus, diabetic retinopathy (DR) is one of the major causes of blindness.It is urgent to […]
Effects of Krüppel-like factor 6 overexpression towards apoptosis of human lens epithelial cells with ultra violetradiation B treatment
Authors: Tian Fang, Zhao Jinzhi, Huang Liangyu, Xu Manhong, Zhang Zhe, Teng He, Zhang Xiaomin, Li Xiaorong, Dong Lijie, Zhang Hong DOI: 10.3760/cma.j.issn.2095-0160.2019.04.004 Published 2019-04-10 Cite as Chin J Exp Ophthalmol, 2019,37(4): 257-262. Abstract [View PDF] [Read Full Text] Objective To investigate the effect of the overexpression of Krüppel-like factor 6 (KLF6) towards the apoptosis of […]
The inhibitory effect of decorin on apoptosis of human lens epithelial cells under high glucose condition and its mechanism
Authors: Xie Dandan, Du Shanshan, Qi Ying, Shao Jingzhi, Zhang Fengyan DOI: 10.3760/cma.j.issn.2095-0160.2019.04.003 Published 2019-04-10 Cite as Chin J Exp Ophthalmol, 2019,37(4): 252-256. Abstract [View PDF] [Read Full Text] Objective To investigate the effects of decorin (DCN) on apoptosis and oxidative stress in human lens epithelial cells (LECs) under high […]