Category: 2022, No. 04

New paradigms of immune regulation in glaucoma during the whole clinical process

Authors: Wu Jian,  Su Wenru,  Zhuo Yehong DOI: 10.3760/cma.j.cn115989-20220314-00104 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 289-293. Abstract Glaucoma is an irreversible blinding eye disease caused by the structural and functional damage of optic nerve induced by pathological increase of intraocular pressure (IOP), characterized by multiple causes and strong heterogeneity.The control of IOP […]

Inhibitory effect of CLC-2 chloride channel targeted blocking on fibrosis of human conjunctival fibroblasts

Authors: Wu Sharengaowa,  Cui Renzhe,  Lu Di,  Ding Haoxuan,  Sun Lixia DOI: 10.3760/cma.j.cn115989-20200609-00410 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 294-302. Abstract Objective To investigate the inhibitory effect of CLC-2 chloride channel targeted blocking on fibrosis of human conjunctival fibroblasts (HConF). Methods HConF were divided into blank control group, lipofectamine 2000 (Lipo2000) group, […]

Specific expression of transmembrane protein 26 in retina and its association with primary open-angle glaucoma

Authors: Yin Yi,  Mao Yao,  Yang Zhenglin,  Huang Lulin DOI: 10.3760/cma.j.cn115989-20200112-00021 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 303-309. Abstract Objective To predict the transmembrane structure of transmembrane protein 26 (TMEM26), observe its expression in human retina and mouse retina, and investigate the relationship between it and primary open-angle glaucoma (POAG). Methods The […]

Inhibitory effect of necrostatin-1 on necroptosis of retinal ganglion cells in rats with acute ocular hypertension

Authors: Jing Yuanyuan,  Ma Yi,  Wang Kai,  Liu Zhuqing DOI: 10.3760/cma.j.cn115989-20191108-00488 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 310-315. Abstract Objective To investigate the inhibitory effect of specific inhibitor of necroptosis necrostatin-1 (Nec-1) on necroptosis of retinal ganglion cells (RGCs) in rats with acute ocular hypertension. Methods Twenty-four adult male Sprague Dawley rats […]

Inhibitory effect of ILK-siRNA-AAV on scar formation after glaucoma filtering surgery in rats

Authors: Xing Yao,  Wang Jianming,  Fan Yazhi,  Xiong Lei,  Wang Wenjing,  Cui Lijun DOI: 10.3760/cma.j.cn115989-20210617-00362 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 316-325. Abstract Objective To investigate the role of integrin-linked kinase (ILK)-small interfering RNA (siRNA)-adeno-associated virus (AAV) in scar formation after glaucoma filtering surgery in rat eyes. Methods Forty-eight Sprague Dawley rats […]

Comparison of macular vessel density changes in early primary open-angle glaucoma with central visual field defects and peripheral visual field defects

Authors: Huo Yanjiao,  Guo Yan,  Wang Huaizhou,  Li Lei,  Wang Ningli DOI: 10.3760/cma.j.cn115989-20211103-00599 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 327-333. Abstract Objective To compare the change of macular microvasculature in early primary open-angle glaucoma (POAG) patients with central visual field defects (CVFDs) and peripheral visual field defects (PVFDs). Methods A cross-sectional study […]

Outcomes and safety of phacoemulsification combined with intraocular lens implantation plus goniosynechialysis and goniotomy for advanced primary angle-closure glaucoma

Authors: Song Yunhe,  Zhang Yingzhe,  Lin Fengbin,  Nie Xin,  Shi Jiguang,  Chen Taifeng,  Liang Xiaohong,  Wang Zhenyu,  Wei Menghuan,  Chen Shuyu,  Zhang Xiulan DOI: 10.3760/cma.j.cn115989-20211215-00692 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 334-339. Abstract Objective To evaluate the effectiveness and safety of phacoemulsification cataract extraction combined with intraocular lens implantation (PEI) plus goniosynechilysis […]

Is Schlemm canal surgery suitable for primary angle-closure glaucoma?

Authors: Tang Li,  Yuan Huiping,  Tang Guangxian,  Fan Sujie,  Lu Lan,  Zhou Minwen,  Xie Lin,  Nie Xin,  Zhang Xiulan DOI: 10.3760/cma.j.cn115989-20211102-00598 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 340-344. Abstract Primary angle-closure glaucoma (PACG) is a common subtype of glaucoma and one of the leading causes of blindness in Asia.Trabeculectomy has been recognized […]

Normal tension glaucoma: reconsideration and reevaluation

Authors: Fan Ning,  Wang Yun,  Tan Junkai,  Wang Ningli,  Liu Xuyang DOI: 10.3760/cma.j.cn115989-20210712-00408 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 345-350. Abstract Normal tension glaucoma (NTG) is almost the most difficult type of glaucoma to diagnose.The difficulty lies in the lack of specificity of the symptoms and signs of glaucomatous optic neuropathy (GON), […]

Research progress of intraocular pressure and its related influencing factors in children

Authors: Han Fang,  Wang Yan DOI: 10.3760/cma.j.cn115989-20200811-00581 Published 2022-04-10 Cite asChin J Exp Ophthalmol, 2022, 40(4): 351-356. Abstract Glaucoma is an irreversible cause of blindness, and elevated intraocular pressure (IOP) is an important risk factor for it.There is no clearly defined value of ocular hypertension in children, thus the accurate evaluation of IOP in children […]