Authors: Chai Fang, Ai Hua, Li Juan, Yang Xinguang DOI: 10.3760/cma.j.issn.2095-0160.2017.04.004 Published 2017-04-10 Cite as Chin J Exp Ophthalmol, 2017,35(4): 300-305. Abstract [Download PDF] [Read Full Text] Background Misfolding of Myocilin protein plays an important role in the pathogenesis of primary open angle glaucoma (POAG). GRP78 can transfer the […]
Category: Experimental Science
Apoptosis and autophagy of retinal ganglion cell-5 cells induced by hydrostatic pressure
Authors: Wang Yuping, Wang Jing, Yuan Yuanzhi DOI: 10.3760/cma.j.issn.2095-0160.2017.04.002 Published 2017-04-10 Cite as Chin J Exp Ophthalmol, 2017,35(4): 293-298. Abstract [Download PDF] [Read Full Text] Background Researches showed that the mitochondrial-mediated apoptosis and autophagy play an important role in the survival of retinal ganglion cells (RGCs) in glaucoma.However, […]
Excitatory toxicity of glutamate on meningothelial cells of optic nerve sheaths and its oxidative stress mechanism
Authors: Xin Xiaorong, Gong Tianxiang, Hong Ying, Dang Hong DOI: 10.3760/cma.j.issn.2095-0160.2017.05.009 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 432-437. Abstract [Download PDF] [Read Full Text] Background Meningothelial cells (MECs) occupy the predominant cell component of barrier between optic nerve and the cerebral spinal fluid, and any change […]
Effects of interleukin-6 in promoting corneal epithelial stem/progenitor cell regeneration and accelerating corneal epithelial wound healing in diabetic mouse
Authors: Dong Yahui, Chen Peng, Zhang Zhenzhen, Feng Lu, Zhou Qingjun DOI: 10.3760/cma.j.issn.2095-0160.2017.05.008 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 423-431. Abstract [Download PDF] [Read Full Text] Background Interleukin-6 (IL-6) is a pleiotropic cytokine involving in inflammation and wound healing.Previous report found that IL-6 […]
The promoting effects of insulin-like growth factor 1 on the biological behaviour of human retinal vascular endothelial cells
Authors: Wang Mengjiao, Liu Gaoqin, Xu Jing, Li Dan, Lu Peirong DOI: 10.3760/cma.j.issn.2095-0160.2017.05.007 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 417-422. Abstract [Download PDF] [Read Full Text] Background The suppression of retinal angiogenesis is one of primary treatment targets for retinal vascular diseases, so seeking the intervention targets […]
A pilot molecular mechanism study on lacrimal gland as a potential human immunodeficiency virus reservoir
Authors: Liu Ziyang, Liu Xiaowei, Ye Junjie, Han Yang, Li Taisheng, Huo Zhen DOI: 10.3760/cma.j.issn.2095-0160.2017.05.005 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 410-415. Abstract [Download PDF] [Read Full Text] Background Acquired immune deficiency syndrome (AIDS) is an infectious disease caused by human immunodeficiency virus (HIV). […]
Protective effect of rapamycin on hypoxia-injuried retinal ganglion cells and its mechanism
Authors: Ren Jing, Qin Bo, Zou Chang, He Jing, Liu Shenwen DOI: 10.3760/cma.j.issn.2095-0160.2017.05.004 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 404-409. Abstract [Download PDF] [Read Full Text] Background Studies showed that rapamycin (Rapa) plays a protective effect on central nervous system by improving the aging of human brain […]
Effects of low-dose of TGF-β1 on maintaining bovine corneal stromal cell growth and retarding extra cellular matrix fibrosis in a three-dimensional culture model
Authors: Zhang Lu, Luo Shinan, Yuan Jianbao, Zhou Weiwei, Li Xia DOI: 10.3760/cma.j.issn.2095-0160.2017.05.003 Published 2017-05-10 Cite as Chin J Exp Ophthalmol, 2017,35(5): 396-403. Abstract [Download PDF] [Read Full Text] Background Transforming growth factor-β1 (TGF-β1) plays an important role in corneal wound healing.The effects of TGF-β1 on the synthesis of extra […]
A comparative study on the inhibitory effects of commonly used clinical drugs on in vitro fibroblasts from recurrent pterygium
Authors: Sun Yajie, Lin Tingting, He Yanjin, Zhu Limin, Gao Yang, Zhou Bo DOI: 10.3760/cma.j.issn.2095-0160.2017.06.006 Published 2017-06-10 Cite as Chin J Exp Ophthalmol, 2017,35(06): 512-519. Abstract [Download PDF] [Read Full Text] Background Pterygium is one of the common ocular surface disorders, and the main drugs for pterygium include dexamethasone (DXM), interferon […]
Influence of high intensity focused ultrasound irradiating cornea on retinas of living rabbits
Authors: Li Meixuan, Du Zhiyu, Wang Menglei, Yan Pisong, Zhang Yu, Li Chongyan DOI: 10.3760/cma.j.issn.2095-0160.2017.06.005 Published 2017-06-10 Cite as Chin J Exp Ophthalmol, 2017,35(06): 506-511. Abstract [Download PDF] [Read Full Text] Background High intensity focused ultrasound (HIFU) is a novel noninvasive technique and it has been used to clinical treatment of […]