·Experimental Research· Establishment of a lens opacity model in Grx2 knockout mice based on the CRISPR/cas9 system and the role of Grx2 in cataract pathogenesis Guo Yong1, Guo Chenjun2, Zhang Jie2, Ning Xiaona2, Chen Xi3, Yan Hong1 1Department of Ophthalmology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Shaanxi Eye Hospital, Xi’an 710004, China; 2Department of Ophthalmology, […]
Category: Experimental Science
Classification of adenoviral conjunctivitis based on sequencing and phylogenetic analysis of hexon and fiber
Authors: Wang Jing, Zhu Jianfeng, Lu Lina DOI: 10.3760/cma.j.cn115989-20200430-00300 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 902-907. Abstract [View PDF] [Read Full Text] Objective To classify human adenovirus (HAdV) of adenoviral conjunctivitis by sequencing and […]
Protective effect of tert-butylhydroquinone on retinal morphology and function in early diabetic rats and its mechanism
·Experimental Research· Protective effects of tert-butylhydroquinone on retinal structure, function and mechanism in early diabetic rat models Wang Juan1, Wei Fang2, Cao Yang1, Tian Min1, Lyu Hongbin1 1Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; 2Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, […]
Inhibitory effect of microRNA-23b-3p on high glucose-induced autophagy and apoptosis of human lens epithelial cells and its mechanism
·Experimental Research· Role and mechanism of microRNA-23b-3p in regulating high glucose-induced autophagy and apoptosis of human lens epithelial cells Liu Wenlan, Wang Li, Yang Yang, Yan Jin School of Medical Technology, Xi’an Medical University, Xi’an 710021, China Corresponding author: Wang Li, Email: 63148645@qq.com [Abstract] […]
Network pharmacology analysis of ginkgo leaves extract against diabetic retinopathy
·Experimental Research· Network pharmacology analysis of ginkgo leaf extract against diabetic retinopathy Bai Wen, Jiang Qin Eye Hospital, Nanjing Medical University, Nanjing 210029, China Corresponding author: Jiang Qin, Email: jqin710@vip.sina.com [Abstract] [View PDF in English] [View PDF in Chinese] [Read Full Text] Objective To identify the key […]
Meibomian gland dysfunction and expressions of inflammatory factors and lipid metabolic factors in diabetic mice
·Experimental research· Meibomian gland dysfunction and expressions of inflammatory factors and lipid metabolic factors in diabetic mice Zou Yuanyuan, Liu Xuemei, Qi Yuanyuan, Zhao Shaozhen Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin […]
Therapeutic effect of anti-IL-12/IL-23 p40 on experimental autoimmune uveitis and its mechanism
·Experimental Research· Therapeutic effect of anti-IL-12/IL-23 p40 on experimental autoimmune uveitis and associated mechanism Cui Xuexue, Zhang Zhihui, Wu Lingzi, Li Yongtao, Chen Shuang, Chen Nu, Zhang Xiaomin Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University […]
Immunoregulatory effects of miR-31-5p overexpression on peripheral blood Th17 cell in a rabbit model of autoimmune dry eye
Authors: Gao Min, Zhao Lu, Chen Sisi, Wei Ruihua, Nian Hong DOI: 10.3760/cma.j.cn115989-20210809-00452 Published 2022-08-10 Cite asChin J Exp Ophthalmol, 2022, 40(8): 716-723. Abstract [View PDF] [Read Full Text] Objective To investigate the immunoregulatory effects of lentivirus-mediated microRNA (miR)-31-5p overexpression on peripheral […]
Inhibitory effect of RMT1-10-induced tolerogenic dendritic cells in vitro on high-risk corneal allograft rejection in mice and its mechanism
Authors: Zhao Min, Yang Liuqing, Wang Mengyu, Tao Yu, Guo Yongyue, Su Ruifeng, Shi Jing, Tan Xiaobo DOI: 10.3760/cma.j.cn115989-20201228-00868 Published 2022-08-10 Cite asChin J Exp Ophthalmol, 2022, 40(8): 725-733. Abstract [View PDF] [Read Full Text] Objective To investigate the inhibitory effect of […]
Inhibitory effect of vorinostat encapsulated hydroxypropyl-β-cyclodextrin eye drops on corneal neovascularization induced by alkali burns in mouse
Authors: Yang Jingjing, Liang Zhen, Lu Ping, Zhang Zhen, Zhang Junjie DOI: 10.3760/cma.j.cn115989-20200807-00566 Published 2022-07-10 Cite asChin J Exp Ophthalmol, 2022, 40(7): 609-616. Abstract [View PDF] [Read Full Text] Objective To prepare vorinostat encapsulated hydroxypropyl-β-cyclodextrin (SAHA-CD) eye drops and investigate its inhibitory […]