Authors: Ma Xiaochen, Liu Hongling DOI: 10.3760/cma.j.cn115989-20190930-00425 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 972-975. Abstract [View PDF] [Read Full Text] The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated endonuclease 9 (Cas9) technology is a gene editing technology that uses […]
Category: 2022
Progress in the research on clinical features of Bestrophinopathies and mutations in BEST1 gene
Authors: Yang Shangying, Sheng Xunlun DOI: 10.3760/cma.j.cn115989-20200921-00659 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 976-980. Abstract [View PDF] [Read Full Text] Bestrophinopathies are a group of inherited macular dystrophies caused by BEST1 gene mutations including Best vitelliform macular dystrophy, adult-onset […]
Epigenetic regulation and retinal degenerative diseases
Authors: Zhang Hua, Pang Jijing DOI: 10.3760/cma.j.cn115989-20191015-00442 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 981-985. Abstract [View PDF] [Read Full Text] Epigenetics pertains to heritable alterations in gene expression when the nucleotide sequence remains unchanged.Epigenetic regulation […]
Role of microRNA-21 in the occurrence and development of ophthalmic diseases
Authors: Sun Jijun, Ruan Qingguo, Shi Weiyun DOI: 10.3760/cma.j.cn115989-20191007-00428 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 986-991. Abstract [View PDF] [Read Full Text] MicroRNA (miRNA) is a short noncoding RNA, which can regulate gene expression.miR-21 is one of the human miRNAs […]
Research progress on regulation of lncRNA in age-related ophthalmopathy
Authors: Cheng Tianyu, Guan Huaijin DOI: 10.3760/cma.j.cn115989-20190125-00035 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 992-995. Abstract [View PDF] [Read Full Text] Long non-coding RNA (lncRNA) is a class of transcripts longer than 200 nucleotides, which do not […]
Advances in rodent models of retinal neovascularization
Authors: Xu Qianhui, Chen Jun, Shao Yi DOI: 10.3760/cma.j.cn115989-20200211-00064 Published 2022-10-10 Cite asChin J Exp Ophthalmol, 2022, 40(10): 996-998. Abstract [View PDF] [Read Full Text] Retinal neovascularization (RNV) originating from retinal blood vessels is one of the main pathological features of many ocular […]
Paying attention to the application of proteomics and metabolomics in clinical and translational research of diabetic retinopathy
Authors: Zhang Hui, Li Xiaorong, Zhou Lei DOI: 10.3760/cma.j.cn115989-20220831-00406 Published 2022-09-10 Cite asChin J Exp Ophthalmol, 2022, 40(9): 791-795. Abstract [View PDF] [Read Full Text] Diabetic retinopathy (DR) is one of the complications of diabetic mellitus and a major cause of blindness […]
Protective effect of tert-butylhydroquinone on retinal morphology and function in early diabetic rats and its mechanism
·Experimental Research· Protective effects of tert-butylhydroquinone on retinal structure, function and mechanism in early diabetic rat models Wang Juan1, Wei Fang2, Cao Yang1, Tian Min1, Lyu Hongbin1 1Department of Ophthalmology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China; 2Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, […]
Inhibitory effect of microRNA-23b-3p on high glucose-induced autophagy and apoptosis of human lens epithelial cells and its mechanism
·Experimental Research· Role and mechanism of microRNA-23b-3p in regulating high glucose-induced autophagy and apoptosis of human lens epithelial cells Liu Wenlan, Wang Li, Yang Yang, Yan Jin School of Medical Technology, Xi’an Medical University, Xi’an 710021, China Corresponding author: Wang Li, Email: 63148645@qq.com [Abstract] […]
Network pharmacology analysis of ginkgo leaves extract against diabetic retinopathy
·Experimental Research· Network pharmacology analysis of ginkgo leaf extract against diabetic retinopathy Bai Wen, Jiang Qin Eye Hospital, Nanjing Medical University, Nanjing 210029, China Corresponding author: Jiang Qin, Email: jqin710@vip.sina.com [Abstract] [View PDF in English] [View PDF in Chinese] [Read Full Text] Objective To identify the key […]