·Experimental Research· Promoting effect of miR-15a on high glucose-induced oxidative stress in human lens epithelial cells and its mechanism Nan Anchao, Nan Jianru, Liu Yadong, Liu Xiangling Department of Ophthalmology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China Corresponding author: Nan Anchao, Email: nananchao0208@163.com Abstract […]
Tag: Lens epithelial cells
Research progress of correlation between microRNA and the pathogenesis of cataract
Authors: Pu Yadi, Li Yuanbin DOI: 10.3760/cma.j.cn115989-20200413-00255 Published 2022-05-10 Cite asChin J Exp Ophthalmol, 2022, 40(5): 475-480. Abstract [View PDF] [Read Full Text] MicroRNA (miRNA) is a kind of small non-coding RNA, which can specifically bind to the 3′ untranslated region of the target RNA, […]
Anti-oxidative stress effects of miR-125b on lens epithelial cells and its mechanism
Authors: Li Xiang, Zhang Ying, Huang Yalin, Wu Zhong, Guo Haoyi DOI: 10.3760/cma.j.cn115989-20191022-00458 Published 2021-04-10 Cite asChin J Exp Ophthalmol, 2021, 39(4): 280-288. Abstract [View PDF] [Read Full Text] Objective To investigate the anti-oxidative stress effects of microRNA 125b (miR-125b) on lens epithelial cells (LECs) […]
Inhibitory effect of siRNA-YAP1 on transforming growth factor β2-induced epithelial-mesenchymal transition in human lens epithelial cells
Authors: Zheng Liu, Hu Chao, Yang Binbin, Yang Xinggang, Ding Zhixiang DOI: 10.3760/cma.j.cn115989-20191016-00447 Published 2021-04-10 Cite asChin J Exp Ophthalmol, 2021, 39(4): 289-296. Abstract [View PDF] [Read Full Text] Objective To investigate the inhibitory effect of small interfering RNA-Yes-associated protein 1 (siRNA-YAP1) on epithelial-mesenchymal transition […]
Regulatory effect of glucocorticoid on the biological function of lens epithelial cells: a bioinformatics analysis
Authors: Yan Chufan, Han Xiao, Zhang Jinsong DOI: 10.3760/cma.j.cn115989-20190821-00359 Published 2021-04-10 Cite asChin J Exp Ophthalmol, 2021, 39(4): 297-303. Abstract [View PDF] [Read Full Text] Objective To analyze the effect of glucocorticoid on the biological function of lens epithelial cells (LECs) by bioinformatics and predict […]
Inhibitory effect and biological mechanism of Dickkopf-1 on the proliferation of human lens epithelial cells
Authors: Zhang Limin, Bao Xiuli DOI: 10.3760/cma.j.cn.115985-20190328-00151 Published 2020-04-10 Cite as Chin J Exp Ophthalmol, 2020,38(04): 285-290. Abstract [View PDF] [Read Full Text] Objective To investigate the effects of Dickkopf-1(DKK1) on the proliferation of human lens epithelial cells (LECs) and its possible mechanism in order to […]
Regulation and its mechanism of MeCP2 on biological behavior and epithelial-mesenchymal transition of LECs
Authors: Niu Chao, Wu Zhong, Huang Yalin, Zhang Ying, Wang Yingfei, Li Xiaohua, Lu Wenlong DOI: 10.3760/cma.j.issn.2095-0160.2020.01.007 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 32-37. Abstract [View PDF] [Read Full Text] Objective To investigate the role of methyl-CpG-binding protein 2 (MeCP2) in the regulation […]
Construction of Smac siRNA lentiviral vector and its silencing effect on Smac gene in human LECs
Authors: Li Yun, Zheng Guangying, Jiang Yu DOI: 10.3760/cma.j.issn.2095-0160.2016.03.002 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 199-204. Abstract [Download PDF] [Read Full Text] Background Research comfirmed that second mitochondrial activator of caspase (Smac) is a promoting tumor cell apoptosis protein.Our previous study showed that the expression […]
Inhibition effects of sulforaphane-induced autophagy flux to cell proliferation on ex vivo human capsular bags
Authors: Liu Hanruo, Yuan Bowei, An Ying, Wan Xiuhua DOI: 10.3760/cma.j.issn.2095-0160.2017.03.009 Published 2017-03-10 Cite as Chin J Exp Ophthalmol, 2017,35(3): 226-232. Abstract [Download PDF] [Read Full Text] Background Sulforaphane (SFN) is an effective chemopreventive agent and can regulate the biological molecular mechanisms to inhibit the overgrowth of cells.Autophagy is […]
Application of RNA interference in posterior capsule opacification by interfering signaling pathway
Authors: Xi Yahui, Liu Hongling DOI: 10.3760/cma.j.issn.2095-0160.2017.12.014 Published 2017-12-10 Cite as Chin J Exp Ophthalmol, 2017,35(12): 1126-1129. Abstract [Download PDF] [Read Full Text] Posterior capsule opacification (PCO) is a common complication after cataract phacoemulsification with intraocular lens (IOL) implantation.The mechanism of lens epithelial […]