Authors: Li Jiancheng, Bu Zhanyun, Pan Junhui DOI: 10.3760/cma.j.cn115989-20200407-00242 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 639-645. Abstract [View PDF] [Read Full Text] Objective To investigate whether microRNA-338-3p (miR-338-3p) affects the proliferation and apoptosis of choroidal microvascular endothelial cells by […]
Tag: Apoptosis
Research progress of survivin gene and eye diseases
Authors: Wang Xiaocong, Tan Wei DOI: 10.3760/cma.j.cn115989-20200509-00322 Published 2020-08-10 Cite as Chin J Exp Ophthalmol, 2020,38(08): 721-725. Abstract [View PDF] [Read Full Text] Survivin is a member of inhibitors of apoptosis protein family, compared with other members, survivin has a unique baculovirus apoptosis inhibitory protein—inhibitor of […]
Inhibitory effect of small interfering RNA-TLR9 on high glucose-induced retinal ganglion cell apoptosis
Authors: Yang Huihui, Kan Quane, Yu Lu, Li Xuqing, Huang Aiguo, Yuan Huijuan DOI: 10.3760/cma.j.issn.2095-0160.2019.10.008 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 38-44. Abstract [View PDF] [Read Full Text] Objective To investigate the effect of Toll-like receptor 9 (TLR9) on high glucose-induced retinal ganglion […]
Anti-apoptotic mechanism of heme oxygenase 1 and its protective role in related ophthalmopathy
Authors: Chen Weiqi, Hong Yu DOI: 10.3760/cma.j.issn.2095-0160.2020.01.015 Published 2020-01-10 Cite as Chin J Exp Ophthalmol, 2020,38(01): 73-76. Abstract [View PDF] [Read Full Text] Heme oxygenase 1 (HO-1) is a stress response protein, and its anti-apoptosis research becomes a new hot spot.In recent years, HO-1 plays an […]
Regulation of TNF-α on cell survival conditions and its relationship with ophthalmological disorders
Authors: Gao Wenna, Yang Liu DOI: 10.3760/cma.j.issn.2095-0160.2019.12.016 Published 2019-12-10 Cite as Chin J Exp Ophthalmol, 2019,37(12): 1029-1033. Abstract [View PDF] [Read Full Text] Tumor necrosis factor-α (TNF-α) is a key molecule of the inflammatory response, and plays a significant role in regulating cell survival and death.Many […]
The protactive effects and mechanisms of cx3cr1 antibody on retinal neuron in rats with ischemia reperfusion injury by intravitreal injection
Authors: Li Juanjuan, Li Yan, Tang Zhiwei DOI: 10.3760/cma.j.issn.2095-0160.2016.01.007 Published 2016-01-10 Cite as Chin J Exp Ophthalmol, 2016,34(1): 35-41. Abstract [Download PDF] [Read Full Text] Background Study confirmed that the active microglia may injure retinal ganglion cells (RGCs) in retinal ischemia reperfusion injury (IRI), and increased cx3cr1 expression is […]
Construction of Smac siRNA lentiviral vector and its silencing effect on Smac gene in human LECs
Authors: Li Yun, Zheng Guangying, Jiang Yu DOI: 10.3760/cma.j.issn.2095-0160.2016.03.002 Published 2016-03-10 Cite as Chin J Exp Ophthalmol, 2016,34(3): 199-204. Abstract [Download PDF] [Read Full Text] Background Research comfirmed that second mitochondrial activator of caspase (Smac) is a promoting tumor cell apoptosis protein.Our previous study showed that the expression […]
A comparative study on protective effect of optical nerve between crocin and erigeron breviscapus in chronic ocular hypertensive rats
Authors：Lyu Bochang, Xu Zhiguo, Chen Tao, Shi Juan, Yang Xinguang DOI: 10.3760/cma.j.issn.2095-0160.2016.11.007 Published 2016-11-10 Cite as Chin J Exp Ophthalmol, 2016,34(11): 990-996. Abstract [Download PDF] [Read Full Text] Background The primary cause of glaucomatous optic nerve damage is apoptosis of nerve cell and disorder of retinal circulation.Erigeron breviscapus is confirmed to have […]
Mechanisms of photoreceptor cell death and potential treatment strategies in retinal detachment
Authors：Li Tong, Sun Xiaodong DOI: 10.3760/cma.j.issn.2095-0160.2016.12.020 Published 2016-12-10 Cite as Chin J Exp Ophthalmol, 2016,34(12): 1140-1144. Abstract [Download PDF] [Read Full Text] Retinal detachment(RD)is one of the most common sight-threatening retinal diseases.Visual acuity is not always restored after successful reattachment of the retina.Photoreceptor cell death has been thought to […]
Dynamic changes of FasL protein expression in retinal tissue with aging in retinal degeneration mice
Authors: Tian J, Li Genlin DOI: 10.3760/cma.j.issn.2095-0160.2017.01.004 Published 2017-01-10 Cite as Chin J Exp Ophthalmol, 2017,35(1): 17-21. Abstract [Download PDF] [Read Full Text] Background Retinal transplantation is a new approach to the treatment of retinal degeneration diseases, and how to avoid or reduce the immune rejection after […]